通过钯催化醛与 1,3-二烯的 ene 型反应合成二烯基烯丙醇。
Dienyl homoallyl alcohols via palladium catalyzed ene-type reaction of aldehydes with 1,3-dienes.
机构信息
Department of Applied Chemistry, Faculty of Engineering, Nagasaki University, Bunkyo-machi, Nagasaki 852-8521, Japan.
出版信息
J Am Chem Soc. 2010 Nov 24;132(46):16346-8. doi: 10.1021/ja1072417. Epub 2010 Oct 28.
PMID:21028812
Abstract
The combination of Pd catalyst and Xantphos ligand in the presence of Et(3)B nicely promotes the allylation of aldehydes with conjugated dienes to provide dienyl homoallyl alcohols in excellent yields. The reaction occurs selectively at the C-C double bond bearing higher electron density.
摘要
钯催化剂和 Xantphos 配体在 Et(3)B 的存在下的组合很好地促进了醛与共轭二烯的烯丙基化反应，以优异的收率提供了二烯基高烯丙醇。反应选择性地发生在具有较高电子密度的 C-C 双键上。
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