樟芝 A-J，来自中国樟芝子实体的具有强细胞毒性和抗炎作用的三萜类化合物。
Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus.
机构信息
Department of Medical Technology, Chung Hua University of Medical Technology, Tainan 717, Taiwan, Republic of China.
出版信息
J Nat Prod. 2010 Nov 29;73(11):1756-62. doi: 10.1021/np1002143. Epub 2010 Oct 28.
Abstract
Ten new triterpenoids, camphoratins A-J (1-10), along with 12 known compounds were isolated from the fruiting body of Taiwanofungus camphoratus. Their structures were established by spectroscopic analysis and chemical methods. Compound 10 is the first example of a naturally occurring ergosteroid with an unusual cis-C/D ring junction. Compounds 2-6 and 11 showed moderate to potent cytotoxicity, with EC(50) values ranging from 0.3 to 3 μM against KB and KB-VIN human cancer cell lines. Compounds 6, 10, 11, 14-16, 18, and 21 exhibited anti-inflammatory NO-production inhibition activity with IC(50) values of less than 5 μM, and were more potent than the nonspecific NOS inhibitor N(ω)-nitro-L-arginine methyl ester.
摘要
从台湾樟芝的子实体中分离得到了 10 个新的三萜类化合物，樟油精 A-J（1-10），以及 12 个已知化合物。通过光谱分析和化学方法确定了它们的结构。化合物 10 是第一个具有不寻常的顺式 C/D 环连接的天然存在的麦角甾醇。化合物 2-6 和 11 表现出中等至较强的细胞毒性，对 KB 和 KB-VIN 人癌细胞系的 EC(50)值范围为 0.3 至 3 μM。化合物 6、10、11、14-16、18 和 21 具有抑制 NO 产生的抗炎活性，IC(50)值小于 5 μM，比非特异性 NOS 抑制剂 N(ω)-硝基-L-精氨酸甲酯更有效。
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