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Antrodia camphorata extract induces replicative senescence in superficial TCC, and inhibits the absolute migration capability in invasive bladder carcinoma cells.樟芝提取物可诱导浅表性移行细胞癌发生复制性衰老，并抑制浸润性膀胱癌细胞的绝对迁移能力。
J Ethnopharmacol. 2007 Jan 3;109(1):93-103. doi: 10.1016/j.jep.2006.07.009. Epub 2006 Jul 11.
2
The inhibitory effect of phenylpropanoid glycosides and iridoid glucosides on free radical production and beta2 integrin expression in human leucocytes.苯丙素苷和环烯醚萜苷对人白细胞自由基产生及β2整合素表达的抑制作用。
J Pharm Pharmacol. 2006 Jan;58(1):129-35. doi: 10.1211/jpp.58.1.0016.
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Taxifolin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-oxidative effect and modulation of NF-kappa B activation.紫杉叶素通过其抗氧化作用和对核因子-κB激活的调节来改善大鼠脑缺血再灌注损伤。
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4
Evaluation of the anti-inflammatory activity of zhankuic acids isolated from the fruiting bodies of Antrodia camphorata.樟芝子实体中分离得到的展奎酸的抗炎活性评价
Planta Med. 2004 Apr;70(4):310-4. doi: 10.1055/s-2004-818941.
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The anti-inflammatory effect of honokiol on neutrophils: mechanisms in the inhibition of reactive oxygen species production.厚朴酚对中性粒细胞的抗炎作用：抑制活性氧生成的机制
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Tamosterone Sulfates: A C-14 Epimeric Pair of Polyhydroxylated Sterols from a New Oceanapiid Sponge Genus.硫酸睾酮：来自一个新的海洋海绵属的一对C-14差向异构多羟基甾醇。
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樟芝 A-J，来自中国樟芝子实体的具有强细胞毒性和抗炎作用的三萜类化合物。

Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus.

机构信息

Department of Medical Technology, Chung Hua University of Medical Technology, Tainan 717, Taiwan, Republic of China.

出版信息

J Nat Prod. 2010 Nov 29;73(11):1756-62. doi: 10.1021/np1002143. Epub 2010 Oct 28.

DOI:10.1021/np1002143
PMID:21028898
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2993773/
Abstract

Ten new triterpenoids, camphoratins A-J (1-10), along with 12 known compounds were isolated from the fruiting body of Taiwanofungus camphoratus. Their structures were established by spectroscopic analysis and chemical methods. Compound 10 is the first example of a naturally occurring ergosteroid with an unusual cis-C/D ring junction. Compounds 2-6 and 11 showed moderate to potent cytotoxicity, with EC(50) values ranging from 0.3 to 3 μM against KB and KB-VIN human cancer cell lines. Compounds 6, 10, 11, 14-16, 18, and 21 exhibited anti-inflammatory NO-production inhibition activity with IC(50) values of less than 5 μM, and were more potent than the nonspecific NOS inhibitor N(ω)-nitro-L-arginine methyl ester.

摘要

从台湾樟芝的子实体中分离得到了 10 个新的三萜类化合物，樟油精 A-J（1-10），以及 12 个已知化合物。通过光谱分析和化学方法确定了它们的结构。化合物 10 是第一个具有不寻常的顺式 C/D 环连接的天然存在的麦角甾醇。化合物 2-6 和 11 表现出中等至较强的细胞毒性，对 KB 和 KB-VIN 人癌细胞系的 EC(50)值范围为 0.3 至 3 μM。化合物 6、10、11、14-16、18 和 21 具有抑制 NO 产生的抗炎活性，IC(50)值小于 5 μM，比非特异性 NOS 抑制剂 N(ω)-硝基-L-精氨酸甲酯更有效。