Zhang Wen-ying, Ma Cheng-bin, Xiao Jin-yin, Zhou Hong-rong
Department of Gynecology, Changning Maternity and Infant Health Hospital, Shanghai, China.
Zhonghua Fu Chan Ke Za Zhi. 2010 Jul;45(7):515-8.
To study the clearance of high risk human papillomavirus (HPV) infection among the women with normal cervical pathologic diagnosis.
One hundred and seventy-two HPV-positive cases with normal cervical pathologic diagnosis were enrolled in the study. The infection status of HPV was monitored during follow-up from Aug 2006 to Aug 2008. The time of HPV infection spontaneous clearance, as well as effect factors, were analyzed.
During follow-up, there were 62.2% (107 cases, 107/172) of the HPV infection cleared. The medium clearance time was 11.3 months (95%CI: 10.6 - 16.6 months). The medium clearance time of aged < 30 years, 30 - 39 years, 40 - 49 years and > 49 years were 11.3, 12.0, 10.9 and 8.5 months, respectively. There were not significant difference among aged intervals (P = 0.384). The virus copies of HPV-clearance cases and persistent-infection were 22.6 and 95.0, respectively. There was not significant difference between groups (P = 0.061).
Most of the high risk HPV infection with normal cervical pathologic diagnosis would spontaneously cleared. Age and HPV copies may play little role in the HPV clearance.
研究宫颈病理诊断正常的女性中高危型人乳头瘤病毒（HPV）感染的清除情况。
选取172例宫颈病理诊断正常的HPV阳性病例纳入研究。于2006年8月至2008年8月随访期间监测HPV感染状态。分析HPV感染自然清除的时间及影响因素。
随访期间，62.2%（107例，107/172）的HPV感染得以清除。平均清除时间为11.3个月（95%CI：10.6 - 16.6个月）。年龄<30岁、30 - 39岁、40 - 49岁及>49岁者的平均清除时间分别为11.3、12.0、10.9及8.5个月。各年龄组间差异无统计学意义（P = 0.384）。HPV清除病例与持续感染病例的病毒拷贝数分别为22.6和95.0。两组间差异无统计学意义（P = 0.061）。
大多数宫颈病理诊断正常的高危型HPV感染可自然清除。年龄和HPV拷贝数对HPV清除可能影响不大。
