Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, USA.
Wiley Interdiscip Rev Syst Biol Med. 2012 Mar-Apr;4(2):193-205. doi: 10.1002/wsbm.163. Epub 2011 Oct 19.
The goal of systems biology is to access and integrate information about the parts (e.g., genes, proteins, cells) of a biological system with a view to computing and predicting the behavior of the system. The past decade has witnessed technological revolutions in the capacity to make high throughput measurements about the behavior of genes, proteins, and cells. Such technologies are widely used in biological research and in medicine, such as toward prognosis and therapy response prediction in cancer patients. More recently, systems biology is being applied to vaccinology, with the goal of: (1) understanding the mechanisms by which vaccines stimulate protective immunity, and (2) predicting the immunogenicity or efficacy of vaccines. Here, we review the recent advances in this area, and highlight the biological and computational challenges posed.
系统生物学的目标是获取和整合生物系统各部分（如基因、蛋白质、细胞）的信息，以便计算和预测系统的行为。过去十年见证了在基因、蛋白质和细胞行为的高通量测量能力方面的技术革命。此类技术在生物学研究和医学中得到广泛应用，例如在癌症患者的预后和治疗反应预测方面。最近，系统生物学正在被应用于疫苗学，其目标是：（1）了解疫苗刺激保护性免疫的机制，以及（2）预测疫苗的免疫原性或疗效。在这里，我们综述了该领域的最新进展，并强调了所提出的生物学和计算方面的挑战。
