通过 Rh(III)催化的丙烯酰胺和炔烃之间的氧化偶联反应合成 2-吡啶酮和亚氨基酯。
Synthesis of 2-pyridones and iminoesters via Rh(III)-catalyzed oxidative coupling between acrylamides and alkynes.
机构信息
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, P. R. China 116023.
出版信息
Org Lett. 2010 Dec 3;12(23):5462-5. doi: 10.1021/ol102306c. Epub 2010 Oct 29.
PMID:21033749
Abstract
Catalytic oxidative coupling between acrylamides and alkynes was achieved using 0.5 mol % loading of RhCp*Cl(2) with Cu(OAc)(2) as an oxidant. 2-Pyridones, iminoesters, and substituted indoles could be obtained as a result of the electronic and steric effects of the substituents in the acrylamides.
摘要
使用[RhCp*Cl(2)]2（负载量为 0.5 mol%）和 Cu(OAc)2 作为氧化剂，实现了丙烯酰胺和炔烃之间的催化氧化偶联。由于丙烯酰胺取代基的电子和空间效应，得到了 2-吡啶酮、亚氨基酯和取代吲哚。
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