脂肪组织来源的干细胞分泌具有趋化和血管生成特性的 CXCL5 细胞因子。
Adipose tissue-derived stem cells secrete CXCL5 cytokine with chemoattractant and angiogenic properties.
机构信息
Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA 94143-0738, USA.
出版信息
Biochem Biophys Res Commun. 2010 Nov 19;402(3):560-4. doi: 10.1016/j.bbrc.2010.10.090. Epub 2010 Oct 27.
Abstract
Adipose tissue-derived stem cells (ADSC) secreted CXCL5 cytokine abundantly and higher passaged ADSC up to passage 6 (P6) secreted more CXCL5 than lower passaged ADSC. Higher passaged ADSC also appeared to express higher levels of CXCL5 receptor, i.e., CXCR2. Both CXCL5 and CXCR2 were localized in the tunica intima and tunica adventitia of blood vessels in adipose tissue. Colocalization with CD34 further indicates their association with the putative ADSC in tunica adventitia. Migration assay indicates chemoattractant effects of CXCL5 on ADSC and HUVEC endothelial cells. CXCL5 also enhanced matrigel-based endothelial tube-like formation of HUVEC.
摘要
脂肪组织来源的干细胞（ADSC）大量分泌 CXCL5 细胞因子，高传代 ADSC（至第 6 代，P6）比低传代 ADSC 分泌更多的 CXCL5。高传代 ADSC 似乎也表现出更高水平的 CXCL5 受体，即 CXCR2。CXCL5 和 CXCR2 均定位于脂肪组织血管的内膜和外膜。与 CD34 的共定位进一步表明它们与外膜中假定的 ADSC 有关。迁移实验表明 CXCL5 对 ADSC 和 HUVEC 内皮细胞的趋化作用。CXCL5 还增强了 HUVEC 在基质胶上的管状内皮样形成。
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