Synlab Centre of Laboratory Diagnostics, Heidelberg, Germany.
BMC Med Genet. 2010 Nov 9;11:157. doi: 10.1186/1471-2350-11-157.
C-reactive protein is a well established marker of inflammation and has been used to predict future cardiovascular disease. It is still controversial if it plays an active role in the development of cardiovascular disease. Recently, polymorphisms in the gene for HNF1α have been linked to the levels of C-reactive protein and coronary artery disease.
We investigated the association of the rs2259816 polymorphism in the HNF1A gene with the circulating level of C-reactive protein and the hazard of coronary artery disease in the LURIC Study cohort.
Compared to CC homozygotes, the level of C-reactive protein was decreased in carriers of at least one A-allele. Each A-allele decreased CRP by approximately 15%. The odds ratio for coronary artery disease was only very slightly increased in carriers of the A-allele and this association did not reach statistical significance.
In the LURIC Study cohort the A-allele of rs2259816 is associated with decreased CRP but not with coronary artery disease.
C 反应蛋白是炎症的一个公认标志物，已被用于预测未来的心血管疾病。它是否在心血管疾病的发展中起积极作用仍存在争议。最近，HNF1α 基因的多态性与 C 反应蛋白和冠状动脉疾病的水平有关。
我们研究了 LURIC 研究队列中 HNF1A 基因 rs2259816 多态性与循环 C 反应蛋白水平和冠状动脉疾病风险之间的关联。
与 CC 纯合子相比，至少携带一个 A 等位基因的携带者的 C 反应蛋白水平降低。每个 A 等位基因使 CRP 降低约 15%。携带 A 等位基因的冠状动脉疾病的比值比仅略有增加，且这种关联没有达到统计学意义。
在 LURIC 研究队列中，rs2259816 的 A 等位基因与 CRP 降低相关，但与冠状动脉疾病无关。
