Brandwein M, Choi H S, Strauchen J, Stoler M, Jagirdar J
Department of Pathology, Mount Sinai School of Medicine, New York, NY.
Virchows Arch A Pathol Anat Histopathol. 1990;416(4):281-6. doi: 10.1007/BF01605288.
We report 5 patients with AIDS who had an unusual spindle cell proliferation in the lymph nodes and skin caused by nontuberculous mycobacteriosis. The spindle cell proliferation in these tissues may mimic a spindle cell neoplasm and pose a diagnostic problem if an infectious aetiology is not suspected. The fibroblast-like spindle cells contained numerous acid fast bacilli. They were strongly positive for antibody markers of monocyte/macrophage and leukocyte derivation: Leu M3, Mo-9, T-200, and HLA-DR, and variably positive for alpha-1 anti-chymotrypsin and lysozyme. Ultrastructurally these spindle cells were predominantly fibroblast-like with poorly developed features of macrophages. These results reveal the dual macrophage and fibroblastic character of the spindle cells and probably imply a functional differentiation rather than a histogenetic one.
我们报告了5例艾滋病患者，他们因非结核分枝杆菌病在淋巴结和皮肤出现了不寻常的梭形细胞增殖。这些组织中的梭形细胞增殖可能会模仿梭形细胞瘤，如果不怀疑有感染性病因，就会带来诊断问题。成纤维细胞样梭形细胞含有大量抗酸杆菌。它们对单核细胞/巨噬细胞和白细胞来源的抗体标志物呈强阳性：Leu M3、Mo-9、T-200和HLA-DR，对α-1抗胰凝乳蛋白酶和溶菌酶呈可变阳性。超微结构上，这些梭形细胞主要成纤维细胞样，巨噬细胞特征发育不良。这些结果揭示了梭形细胞的巨噬细胞和成纤维细胞双重特性，可能意味着功能分化而非组织发生分化。
