Laboratoire de Technologie Alimentaire et Nutrition, Université de Mostaganem, Mostaganem, Algeria.
Int J Mol Med. 2011 Jan;27(1):95-102. doi: 10.3892/ijmm.2010.556. Epub 2010 Nov 10.
The present report concerns several post-mortem variables examined in sand rats that were either maintained on a vegetal diet (control animals) or exposed first during a 20-day transition period to a mixed diet consisting of a fixed amount of a hypercaloric food and decreasing amounts of the vegetal food and then to a 30-day experimental period of exposure to the hypercaloric food. During the latter period, all animals were either given free access to food or fasting daily for 15 h, i.e. from 5.00 p.m. to 8.00 a.m. The body weight, liver wet weight, pancreas wet weight, plasma glucose and haemoglobin A1c concentration, plasma insulin concentration, insulinogenic index, insulin resistance HOMA, plasma cholesterol and triglyceride concentration, liver triglyceride and phospholipid content were all measured. Pancreatic islet (insulin, GLUT2) and liver (lipid droplets) histology were also examined. The main findings consisted in a lower body weight of fasting than non-fasting animals, a higher liver weight in non-diabetic and diabetic rats than in control non-fasting (but not so in fasting) animals, a decrease of pancreas weight in non-diabetic and diabetic as distinct from control animals, a fasting-induced decrease in plasma glucose, plasma insulin and insulin resistance HOMA, plasma cholesterol and triglyceride concentration and triglyceride liver content.
本报告涉及沙鼠的几种死后变量，这些沙鼠或维持植物性饮食（对照动物），或首先在 20 天的过渡期内暴露于由固定量的高热量食物和逐渐减少的植物性食物组成的混合饮食中，然后在 30 天的暴露于高热量食物的实验期内暴露。在后者期间，所有动物要么自由进食，要么每天禁食 15 小时，即从下午 5 点到上午 8 点。测量了体重、肝湿重、胰腺湿重、血浆葡萄糖和血红蛋白 A1c 浓度、血浆胰岛素浓度、胰岛素生成指数、胰岛素抵抗 HOMA、血浆胆固醇和甘油三酯浓度、肝甘油三酯和磷脂含量。还检查了胰岛（胰岛素、GLUT2）和肝脏（脂滴）组织学。主要发现包括禁食动物的体重低于非禁食动物，非糖尿病和糖尿病大鼠的肝重高于对照非禁食（但禁食动物则不然）动物，非糖尿病和糖尿病大鼠的胰腺重量下降与对照动物不同，禁食引起的血浆葡萄糖、胰岛素和胰岛素抵抗 HOMA、血浆胆固醇和甘油三酯浓度以及甘油三酯肝含量降低。
