School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
Eur J Appl Physiol. 2011 Jun;111(6):925-36. doi: 10.1007/s00421-010-1718-x. Epub 2010 Nov 11.
There is no consensus regarding the effects of mixed antioxidant vitamin C and/or vitamin E supplementation on oxidative stress responses to exercise and restoration of muscle function. Thirty-eight men were randomly assigned to receive either placebo group (n = 18) or mixed antioxidant (primarily vitamin C & E) supplements (n = 20) in a double-blind manner. After 6 weeks, participants performed 90 min of intermittent shuttle-running. Peak isometric torque of the knee flexors/extensors and range of motion at this joint were determined before and after exercise, with recovery of these variables tracked for up to 168 h post-exercise. Antioxidant supplementation elevated pre-exercise plasma vitamin C (93 ± 8 μmol l(-1)) and vitamin E (11 ± 3 μmol l(-1)) concentrations relative to baseline (P < 0.001) and the placebo group (P ≤ 0.02). Exercise reduced peak isometric torque (i.e. 9-19% relative to baseline; P ≤ 0.001), which persisted for the first 48 h of recovery with no difference between treatment groups. In contrast, changes in the urine concentration of F(2)-isoprostanes responded differently to each treatment (P = 0.04), with a tendency for higher concentrations after 48 h of recovery in the supplemented group (6.2 ± 6.1 vs. 3.7 ± 3.4 ng ml(-1)). Vitamin C & E supplementation also affected serum cortisol concentrations, with an attenuated increase from baseline to the peak values reached after 1 h of recovery compared with the placebo group (P = 0.02) and serum interleukin-6 concentrations were higher after 1 h of recovery in the antioxidant group (11.3 ± 3.4 pg ml(-1)) than the placebo group (6.2 ± 3.8 pg ml(-1); P = 0.05). Combined vitamin C & E supplementation neither reduced markers of oxidative stress or inflammation nor did it facilitate recovery of muscle function after exercise-induced muscle damage.
关于混合抗氧化维生素 C 和/或维生素 E 补充剂对运动引起的氧化应激反应和肌肉功能恢复的影响，目前尚无共识。38 名男性被随机分为安慰剂组（n = 18）或混合抗氧化剂（主要是维生素 C 和 E）补充剂组（n = 20），采用双盲法。6 周后，参与者进行 90 分钟的间歇性穿梭跑。在运动前后测定膝关节屈肌/伸肌的最大等长扭矩和该关节的活动范围，在运动后最多 168 小时跟踪这些变量的恢复情况。抗氧化剂补充剂使运动前血浆维生素 C（93 ± 8 μmol l(-1)）和维生素 E（11 ± 3 μmol l(-1)）浓度升高，与基线（P < 0.001）和安慰剂组（P ≤ 0.02）相比。运动降低了最大等长扭矩（即相对于基线降低 9-19%；P ≤ 0.001），在恢复的前 48 小时持续存在，两组之间无差异。相比之下，尿液中 F(2)-异前列腺素浓度的变化对每种治疗的反应不同（P = 0.04），补充组在恢复 48 小时后浓度有升高趋势（6.2 ± 6.1 与 3.7 ± 3.4 ng ml(-1)）。维生素 C 和 E 补充剂还影响血清皮质醇浓度，与安慰剂组相比，从基线到恢复 1 小时后达到的峰值，皮质醇浓度的增加幅度降低（P = 0.02），且在抗氧化剂组中，恢复 1 小时后血清白细胞介素-6 浓度较高（11.3 ± 3.4 pg ml(-1)）比安慰剂组（6.2 ± 3.8 pg ml(-1)；P = 0.05）。维生素 C 和 E 的联合补充既不能降低氧化应激或炎症标志物的水平，也不能促进运动引起的肌肉损伤后的肌肉功能恢复。
