Clinica Pediatrica Università di Verona, Verona, Italy.
Pediatr Allergy Immunol. 2010 Dec;21(8):1139-45. doi: 10.1111/j.1399-3038.2010.00989.x.
The evaluation of nasal nitric oxide (nNO) has been proposed as a screening tool in children with clinically suspectable primary ciliary dyskinesia. Nevertheless, normal values have been reported for school-aged children. This study was designed to identify normal nNO levels in pre-school children. nNO was assessed in 300 healthy children aged between 1.5 and 7.2. Two hundred and fifty of them were unable to fulfill the guideline requirements for nNO measurement and were assessed by sampling the nasal air continuously with a constant trans-nasal aspiration flow for 30 s during tidal breathing. For those children who were able to cooperate, the average nNO concentration was calculated according to guidelines. A statistically significant relationship between nNO level and age was demonstrated in this study group of pre-school children (p < 0.001). An increase in nNO of about 100 ppb was observed in children older than 6 yr vs. those aged < 3. This study presents a description of normal nNO values in pre-school children. The effect of the age and the eventual presence of rhinitis and snoring need to be considered whenever nNO is evaluated in the clinical practice, in particular in non-cooperative children.
鼻一氧化氮（nNO）的评估已被提议作为临床疑似原发性纤毛运动障碍儿童的筛查工具。然而，已经报道了学龄儿童的正常值。本研究旨在确定学龄前儿童的正常 nNO 水平。评估了 300 名年龄在 1.5 至 7.2 岁之间的健康儿童的 nNO。其中 250 名儿童无法满足 nNO 测量的指南要求，并通过在潮式呼吸期间用恒定的经鼻抽吸流量连续采样鼻腔空气 30 秒来评估。对于能够合作的儿童，根据指南计算平均 nNO 浓度。本研究表明，在该学龄前儿童研究组中，nNO 水平与年龄之间存在显著的统计学关系（p < 0.001）。与年龄<3 岁的儿童相比，年龄>6 岁的儿童的 nNO 增加约 100 ppb。本研究介绍了学龄前儿童正常 nNO 值的描述。在临床实践中评估 nNO 时，无论在何种情况下，都需要考虑年龄以及鼻炎和打鼾的存在与否，尤其是在不合作的儿童中。
