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6至18岁健康中国儿童的鼻腔一氧化氮

Nasal nitric oxide in healthy Chinese children aged 6-18 years.

作者信息

Wu Yufen, Zhang Hao, Wang Jinrong, Han Yuling, Shi Yongsheng, Zhang Qiaoling, Shen Li, Jiang Haohua, Jia Chunmei, Yu Yanyan, Long Zhen, Ji Minghong, Liu Aihong, Pan Chunhong, Ma Dongjun, Wu Jinhong, Dai Fuli

机构信息

Department of internal medicine, Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.

Pediatric Respiratory Department, The First Affiliate Hospital of Shandong Provincial Medical University, Shandong, China.

出版信息

Front Pediatr. 2023 May 9;11:990510. doi: 10.3389/fped.2023.990510. eCollection 2023.

DOI:10.3389/fped.2023.990510
PMID:37228434
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10203522/
Abstract

OBJECTIVES

To obtain the normal values of fractional concentration of nasal nitric oxide in Chinese children aged 6-18 years, so as to provide reference for clinical diagnosis.

METHODS

2,580 out of 3,200 children (1,359 males and 1,221 females), whom were included from 12 centers around China were taken tests, their height and weight were also recorded. Data were used to analyze the normal range and influencing factors of fractional concentration of nasal nitric oxide values.

MEASUREMENTS

Data was measured using the Nano Coulomb Breath Analyzer (Sunvou-CA2122, Wuxi, China), according to the American Thoracic Society/European Respiratory Society (ATS/ERS) recommendations.

MAIN RESULTS

We calculated the normal range and prediction equation of fractional concentration of nasal nitric oxide values in Chinese children aged 6-18 years. The mean FnNO values of Chinese aged 6-18 yrs was 454.5 ± 176.2 ppb, and 95% of them were in the range of 134.5-844.0 ppb. The prediction rule of FnNO values for Chinese children aged 6-11 yrs was: FnNO = 298.881 + 17.974 × age. And for children aged 12-18 yrs was: FnNO = 579.222-30.332 × (male = 0, female = 1)-5.503 × age.

CONCLUSIONS

Sex and age were two significant predictors of FnNO values for Chinese children(aged 12-18 yrs). Hopefully this study can provide some reference value for clinical diagnosis in children.

摘要

目的

获取6-18岁中国儿童鼻腔一氧化氮分数浓度的正常值，为临床诊断提供参考。

方法

从中国12个中心纳入的3200名儿童中选取2580名（男1359名，女1221名）进行检测，并记录其身高和体重。对数据进行分析，以确定鼻腔一氧化氮分数浓度值的正常范围及影响因素。

测量

根据美国胸科学会/欧洲呼吸学会（ATS/ERS）的建议，使用纳米库仑呼吸分析仪（中国无锡Sunvou-CA2122）测量数据。

主要结果

我们计算了6-18岁中国儿童鼻腔一氧化氮分数浓度值的正常范围及预测方程。6-18岁中国儿童的平均FnNO值为454.5±176.2 ppb，其中95%在134.5-844.0 ppb范围内。6-11岁中国儿童FnNO值的预测规则为：FnNO = 298.881 + 17.974×年龄。12-18岁儿童的预测规则为：FnNO = 579.222 - 30.332×（男性=0，女性=1）- 5.503×年龄。

结论

性别和年龄是中国儿童（12-18岁）FnNO值的两个重要预测因素。希望本研究能为儿童临床诊断提供一定参考价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09f9/10203522/2516a28c2842/fped-11-990510-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09f9/10203522/0ef160052c77/fped-11-990510-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09f9/10203522/a7aede83fb28/fped-11-990510-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09f9/10203522/d406ad636046/fped-11-990510-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09f9/10203522/2516a28c2842/fped-11-990510-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09f9/10203522/0ef160052c77/fped-11-990510-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09f9/10203522/a7aede83fb28/fped-11-990510-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09f9/10203522/d406ad636046/fped-11-990510-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09f9/10203522/2516a28c2842/fped-11-990510-g004.jpg

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Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis.中华医学会变态反应学分会变应性鼻炎诊断和治疗指南
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