The University of Texas Health Science Center Houston, Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
Phys Med Biol. 2010 Dec 7;55(23):6999-7008. doi: 10.1088/0031-9155/55/23/S03. Epub 2010 Nov 12.
The dosimetric accuracy of treatment planning systems (TPSs) decreases for locations outside the treatment field borders. However, the true accuracy of specific TPSs for locations beyond the treatment field borders is not well documented. Our objective was to quantify the accuracy of out-of-field dose predicted by the commercially available Eclipse version 8.6 TPS (Varian Medical Systems, Palo Alto, CA) for a clinical treatment delivered on a Varian Clinac 2100. We calculated (in the TPS) and determined (with thermoluminescent dosimeters) doses at a total of 238 points of measurement (with distance from the field edge ranging from 3.75 to 11.25 cm). Our comparisons determined that the Eclipse TPS underestimated out-of-field doses by an average of 40% over the range of distances examined. As the distance from the treatment field increased, the TPS underestimated the dose with increasing magnitude--up to 55% at 11.25 cm from the treatment field border. These data confirm that accuracy beyond the treatment border is inadequate, and out-of-field data from TPSs should be used only with a clear understanding of this limitation. Studies that require accurate out-of-field dose should use other dose reconstruction methods, such as direct measurements or Monte Carlo calculations.
治疗计划系统 (TPS) 的剂量学准确性随着治疗野外边界外的位置而降低。然而,特定 TPS 在治疗野外边界之外的位置的实际准确性尚未得到很好的记录。我们的目的是量化由商业上可用的 Eclipse 版本 8.6 TPS(Varian Medical Systems,Palo Alto,CA)预测的临床治疗在 Varian Clinac 2100 上进行时的野外剂量的准确性。我们在 TPS 中计算(并使用热释光剂量计)总共 238 个测量点的剂量(距离野外边缘的距离从 3.75 厘米到 11.25 厘米不等)。我们的比较确定,Eclipse TPS 在检查的距离范围内平均低估了野外剂量的 40%。随着距离治疗场的增加,TPS 以越来越大的幅度低估剂量 - 在距治疗场边界 11.25 厘米处高达 55%。这些数据证实,治疗边界之外的准确性不足,并且 TPS 的野外数据仅应在明确了解此限制的情况下使用。需要准确的野外剂量的研究应使用其他剂量重建方法,例如直接测量或蒙特卡罗计算。