Department of Neurology and Rehabilitation, University of Illinois, Chicago, IL, United States; Department of Bioengineering, University of Illinois, Chicago, IL, United States.
Department of Neurology and Rehabilitation, University of Illinois, Chicago, IL, United States.
Clin Neurophysiol. 2019 Feb;130(2):270-279. doi: 10.1016/j.clinph.2018.11.025. Epub 2018 Dec 19.
Interictal spikes are a biomarker of epilepsy, yet their precise roles are poorly understood. Using long-term neocortical recordings from epileptic patients, we investigated the spatial-temporal propagation patterns of interictal spiking.
Interictal spikes were detected in 10 epileptic patients. Short time direct directed transfer function was used to map the spatial-temporal patterns of interictal spike onset and propagation across different cortical topographies.
Each patient had unique interictal spike propagation pattern that was highly consistent across times, regardless of the frequency band. High spiking brain regions were often not spike onset regions. We observed frequent spike propagations to shorter distances and that the central sulcus forms a strong barrier to spike propagation. Spike onset and seizure onset seemed to be distinct networks in most cases.
Patients in epilepsy have distinct and unique network of causal propagation pattern which are very consistent revealing the underlying epileptic network. Although spike are epileptic biomarkers, spike origin and seizure onset seems to be distinct in most cases.
Understanding patterns of interictal spike propagation could lead to the identification patient-specific epileptic networks amenable to surgical or other treatments.
发作间期棘波是癫痫的生物标志物，但它们的确切作用仍不清楚。本研究使用癫痫患者的长期皮质记录，研究了发作间期棘波的时空传播模式。
在 10 名癫痫患者中检测到发作间期棘波。采用短时间直接有向传递函数来绘制发作间期棘波起始和传播的时空模式，跨越不同的皮质拓扑。
每位患者的发作间期棘波传播模式均具有独特性，且在不同频段下均具有高度一致性。高棘波脑区通常不是棘波起始区。我们观察到频繁的棘波向较短距离传播，中央沟形成棘波传播的强屏障。在大多数情况下，棘波起始和癫痫发作似乎是不同的网络。
癫痫患者具有独特且一致的因果传播模式网络，这揭示了潜在的癫痫网络。尽管棘波是癫痫的生物标志物，但在大多数情况下，棘波起源和癫痫发作似乎是不同的。
了解发作间期棘波传播模式可以识别适合手术或其他治疗的特定于患者的癫痫网络。
