聚合物胶束的应变促进炔基-叠氮环加成表面修饰。
Surface modification of polymeric micelles by strain-promoted alkyne-azide cycloadditions.
机构信息
Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.
出版信息
Chemistry. 2010 Dec 3;16(45):13360-6. doi: 10.1002/chem.201002532.
Abstract
Organomicelles modified by surface dibenzylcyclooctyne moieties can conveniently be functionalized by strain-promoted alkyne-azide cycloadditions. The ligation approach is highly efficient, does not require toxic reagents and is compatible with a wide variety of functional modules. Interactions of proteins with surface ligands of the micelles have been studied by AFM, which revealed that it leads to disassembly of the particles thereby providing a mechanism for triggered drug release.
摘要
经表面二苄基环辛炔基修饰的细胞器可通过应变促进的炔基-叠氮环加成反应方便地进行功能化。该连接方法效率高，不需要有毒试剂，并且与各种功能模块兼容。通过原子力显微镜研究了蛋白质与胶束表面配体的相互作用，结果表明这导致了颗粒的解体，从而为触发药物释放提供了一种机制。
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