Department of Chemistry, University of California, Berkeley, CA 94720, USA.
Chem Soc Rev. 2010 Apr;39(4):1272-9. doi: 10.1039/b901970g.
Bioorthogonal chemical reactions are paving the way for new innovations in biology. These reactions possess extreme selectivity and biocompatibility, such that their participating reagents can form covalent bonds within richly functionalized biological systems--in some cases, living organisms. This tutorial review will summarize the history of this emerging field, as well as recent progress in the development and application of bioorthogonal copper-free click cycloaddition reactions.
生物正交化学反应为生物学的新创新铺平了道路。这些反应具有极高的选择性和生物相容性，以至于它们的参与试剂可以在富含功能化的生物体系——某些情况下是活体生物体内形成共价键。本综述将总结这一新兴领域的历史，以及生物正交无铜点击环加成反应的发展和应用的最新进展。
