Department of Chemistry, University of California, Berkeley, California 94720, USA.
J Am Chem Soc. 2010 Dec 8;132(48):17071-3. doi: 10.1021/ja107783j. Epub 2010 Nov 15.
Hydrogen peroxide (H2O2) can exert diverse signaling and stress responses within living systems depending on its spatial and temporal dynamics. Here we report a new small-molecule probe for producing H2O2 on demand upon photoactivation and its application for optical regulation of cofilin-actin rod formation in living cells. This chemical method offers many potential opportunities for dissecting biological roles for H2O2 as well as remote control of cell behavior via H2O2-mediated pathways.
过氧化氢（H2O2）可以根据其时空动态在活系统中发挥多种信号转导和应激反应。在这里，我们报道了一种新的小分子探针，用于在光激活时按需产生 H2O2，并将其应用于活细胞中肌动蛋白丝形成的光学调节。这种化学方法为解析 H2O2 的生物学作用以及通过 H2O2 介导的途径对细胞行为进行远程控制提供了许多潜在的机会。
