从感染 HIV 的母亲和婴儿中进行病毒序列分析：母婴传播的分子进化、多样性和危险因素。
Viral sequence analysis from HIV-infected mothers and infants: molecular evolution, diversity, and risk factors for mother-to-child transmission.
机构信息
Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305-4200, USA.
出版信息
Clin Perinatol. 2010 Dec;37(4):739-50, viii. doi: 10.1016/j.clp.2010.08.003.
Abstract
Great progress has been made in understanding the pathogenesis, treatment, and transmission of HIV and the factors influencing the risk of mother-to-child transmission (MTCT). Many questions regarding the molecular evolution and genetic diversity of HIV in the context of MTCT remain unanswered. Further research to identify the selective factors governing which variants are transmitted, how the compartmentalization of HIV in different cells and tissues contributes to transmission, and the influence of host immunity, viral diversity, and recombination on MTCT may provide insight into new prevention strategies and the development of an effective HIV vaccine.
摘要
在理解 HIV 的发病机制、治疗方法和传播途径以及影响母婴传播（MTCT）风险的因素方面已经取得了重大进展。然而，关于 MTCT 背景下 HIV 的分子进化和遗传多样性仍有许多问题尚未得到解答。进一步的研究旨在确定哪些变异体被传播的选择因素，HIV 在不同细胞和组织中的分隔如何促进传播，以及宿主免疫、病毒多样性和重组对 MTCT 的影响，这些研究可能为新的预防策略和有效的 HIV 疫苗的开发提供深入了解。
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