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本文引用的文献

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Restriction of HIV-1 genotypes in breast milk does not account for the population transmission genetic bottleneck that occurs following transmission.母乳中 HIV-1 基因型的限制并不能说明传播后发生的人群传播遗传瓶颈。
PLoS One. 2010 Apr 20;5(4):e10213. doi: 10.1371/journal.pone.0010213.
2
Prevention in neglected subpopulations: prevention of mother-to-child transmission of HIV infection.被忽视人群的预防：预防艾滋病毒母婴传播。
Clin Infect Dis. 2010 May 15;50 Suppl 3:S130-48. doi: 10.1086/651484.
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Accelerating HIV vaccine development.加速艾滋病病毒疫苗的研发。
Nature. 2010 Mar 11;464(7286):161-2. doi: 10.1038/464161a.
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Universal antiretroviral therapy for pregnant and breast-feeding HIV-1-infected women: towards the elimination of mother-to-child transmission of HIV-1 in resource-limited settings.为感染 HIV-1 的孕妇和哺乳期妇女提供普遍的抗逆转录病毒治疗：在资源有限的环境下消除 HIV-1 的母婴传播。
Clin Infect Dis. 2009 Dec 15;49(12):1936-45. doi: 10.1086/648446.
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Potential impact of viral load and genetic makeup of HIV type 1 on mother-to-child transmission: characterization of env-C2V3C3 and nef sequences.1型人类免疫缺陷病毒的病毒载量和基因组成对母婴传播的潜在影响：env-C2V3C3和nef序列的特征分析
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Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand.在泰国使用ALVAC和AIDSVAX疫苗预防HIV-1感染。
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7
HAART during pregnancy and during breastfeeding among HIV-infected women in the developing world: has the time come?发展中世界感染艾滋病毒妇女在孕期和哺乳期的高效抗逆转录病毒治疗：时机已到？
AIDS. 2009 Nov 27;23(18):2473-7. doi: 10.1097/QAD.0b013e328333866c.
8
Evolution and molecular epidemiology of subtype C HIV-1 in Zimbabwe.津巴布韦 C 亚型 HIV-1 的进化和分子流行病学。
AIDS. 2009 Nov 27;23(18):2523-32. doi: 10.1097/QAD.0b013e3283320ef3.
9
Multidrug-resistant variants of HIV type 1 (HIV-1) can exist in cells as defective quasispecies and be rescued by superinfection with other defective HIV-1 variants.1型人类免疫缺陷病毒（HIV-1）的多重耐药变异体可作为缺陷准种存在于细胞中，并可通过与其他缺陷HIV-1变异体的双重感染而得到拯救。
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10
Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target.一位非洲捐赠者体内广泛且强效的中和抗体揭示了一个新的HIV-1疫苗靶点。
Science. 2009 Oct 9;326(5950):285-9. doi: 10.1126/science.1178746. Epub 2009 Sep 3.

从感染 HIV 的母亲和婴儿中进行病毒序列分析：母婴传播的分子进化、多样性和危险因素。

Viral sequence analysis from HIV-infected mothers and infants: molecular evolution, diversity, and risk factors for mother-to-child transmission.

机构信息

Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305-4200, USA.

出版信息

Clin Perinatol. 2010 Dec;37(4):739-50, viii. doi: 10.1016/j.clp.2010.08.003.

DOI:10.1016/j.clp.2010.08.003
PMID:21078447
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3175486/
Abstract

Great progress has been made in understanding the pathogenesis, treatment, and transmission of HIV and the factors influencing the risk of mother-to-child transmission (MTCT). Many questions regarding the molecular evolution and genetic diversity of HIV in the context of MTCT remain unanswered. Further research to identify the selective factors governing which variants are transmitted, how the compartmentalization of HIV in different cells and tissues contributes to transmission, and the influence of host immunity, viral diversity, and recombination on MTCT may provide insight into new prevention strategies and the development of an effective HIV vaccine.

摘要

在理解 HIV 的发病机制、治疗方法和传播途径以及影响母婴传播（MTCT）风险的因素方面已经取得了重大进展。然而，关于 MTCT 背景下 HIV 的分子进化和遗传多样性仍有许多问题尚未得到解答。进一步的研究旨在确定哪些变异体被传播的选择因素，HIV 在不同细胞和组织中的分隔如何促进传播，以及宿主免疫、病毒多样性和重组对 MTCT 的影响，这些研究可能为新的预防策略和有效的 HIV 疫苗的开发提供深入了解。