Faculty of Life Sciences, University of Manchester, Manchester, UK.
Cont Lens Anterior Eye. 2011 Feb;34(1):26-31. doi: 10.1016/j.clae.2010.10.006.
To investigate the relationship between refractive error and ocular biometry in healthy subjects using a new optical low coherence reflectometry device.
Biometric measurements were obtained with a LenStar LS 900 (Haag Streit, Switzerland) on one eye of 70 phakic subjects (mean ± SD age; 29 ± 9 years). Forty myopes and 30 non-myopes (best sphere range -9.63 D to +0.63 D) were included. Outcome measures were compared for the two groups using one way between groups ANOVA. These included; keratometry, central corneal thickness, iris width, anterior chamber depth, pupil diameter, lens thickness, axial length and retinal thickness. No mydriatic or cycloplegic agents were used.
There were significant differences between groups for keratometry readings (p = 0.021 and p = 0.038 for steep and flat k readings respectively), anterior chamber depth (p = 0.001), lens thickness (p = 0.026) and axial length (p<0.001). As expected significant correlations were found between spherical equivalent power and axial length (Pearson product-moment correlation r = -0.75, p<0.001) and between spherical equivalent power and anterior chamber depth (r = -0.29, p = 0.018). Anterior chamber depth and pupil diameter decreased with age (r = -0.429, p<0.001 and r = -0.386, p = 0.001 respectively) whereas lens thickness increased with age (r = 0.618, p < 0.001).
Our data showed significant differences between myopes and non-myopes for the key biometric parameters assessed and provides information about the relationships between these biometric parameters and age. The results, coupled with a unique ability to image and analyse the ocular structures non-invasively make the LenStar a promising new instrument for ocular evaluation in research and clinical practice.
使用新型光学低相干反射仪研究健康受试者的屈光不正与眼生物测量之间的关系。
对 70 名正视眼受试者（平均年龄 ± 标准差；29 ± 9 岁）的一只眼进行生物测量。纳入 40 名近视患者和 30 名非近视患者（最佳球镜范围-9.63D 至+0.63D）。使用单向组间方差分析比较两组之间的结果测量值。这些参数包括角膜曲率计、中央角膜厚度、虹膜宽度、前房深度、瞳孔直径、晶状体厚度、眼轴和视网膜厚度。未使用散瞳或睫状肌麻痹剂。
两组间的角膜曲率计读数（陡峭角膜曲率计读数 p=0.021，平坦角膜曲率计读数 p=0.038）、前房深度（p=0.001）、晶状体厚度（p=0.026）和眼轴长度（p<0.001）存在显著差异。正如预期的那样，在等效球镜度数和眼轴长度之间发现了显著的相关性（Pearson 积矩相关 r=-0.75，p<0.001），以及在等效球镜度数和前房深度之间发现了显著相关性（r=-0.29，p=0.018）。前房深度和瞳孔直径随年龄增长而降低（r=-0.429，p<0.001 和 r=-0.386，p=0.001），而晶状体厚度随年龄增长而增加（r=0.618，p<0.001）。
我们的数据显示，在评估的关键生物测量参数方面，近视患者和非近视患者之间存在显著差异，并提供了这些生物测量参数与年龄之间关系的信息。这些结果，加上独特的非侵入性成像和分析眼部结构的能力，使 LenStar 成为研究和临床实践中眼部评估的一种有前途的新仪器。
