Bailey Ryan C
Bioanalysis. 2009 Sep;1(6):1043-7. doi: 10.4155/bio.09.101.
The ability to determine expression levels of multiple genetic and/or proteomic signatures simultaneously from the same sample volume is of tremendous importance in a wide range of biomedical applications, including disease diagnostics, drug discovery and fundamental studies of complex biological processes. Unfortunately, many of the tremendously enabling genomic and proteomic technologies available to the academic are not applicable in the clinical setting. Combining traditional chemical and biological insight with cutting-edge concepts from materials science, physics and engineering, our group brings an interdisciplinary approach to developing new tools in order to tackle longstanding refractory problems in the biological sciences - technologies that will enable fundamental biological discovery and, in some applications, expedite the transfer of biomolecular insight to the hands of the physician, where it can directly impact patient care.
能够从相同体积的样本中同时测定多种基因和/或蛋白质组学特征的表达水平，在包括疾病诊断、药物研发以及复杂生物过程的基础研究等广泛的生物医学应用中具有极其重要的意义。不幸的是，许多学术领域可用的极具潜力的基因组学和蛋白质组学技术并不适用于临床环境。我们的团队将传统的化学和生物学见解与材料科学、物理学和工程学的前沿理念相结合，采用跨学科方法开发新工具，以解决生物科学中长期存在的棘手问题——这些技术将推动基础生物学发现，并且在某些应用中，加快将生物分子见解传递到医生手中，从而直接影响患者护理。
