Department of Biological Science, Florida State University, Tallahassee, 32306-4295, USA.
Nat Rev Genet. 2010 Dec;11(12):855-66. doi: 10.1038/nrg2897.
A key goal of biology is to understand phenotypic characteristics, such as health, disease and evolutionary fitness. Phenotypic variation is produced through a complex web of interactions between genotype and environment, and such a 'genotype-phenotype' map is inaccessible without the detailed phenotypic data that allow these interactions to be studied. Despite this need, our ability to characterize phenomes - the full set of phenotypes of an individual - lags behind our ability to characterize genomes. Phenomics should be recognized and pursued as an independent discipline to enable the development and adoption of high-throughput and high-dimensional phenotyping.
生物学的一个主要目标是了解表型特征，例如健康、疾病和进化适应性。表型变异是由基因型和环境之间的复杂相互作用产生的，如果没有详细的表型数据来研究这些相互作用，就无法获得这种“基因型-表型”图谱。尽管有这种需求，但我们描述表型组（个体的全部表型）的能力仍落后于我们描述基因组的能力。应当将表型组学视为一个独立的学科来加以认识和追求，以促成高通量和高维度表型分析的发展和采用。
