利用磁共振成像对肝脏脂肪进行定量分析。
Quantification of liver fat with magnetic resonance imaging.
作者信息
Reeder Scott B, Sirlin Claude B
机构信息
Liver Imaging Research Program, Department of Radiology, University of Wisconsin, E1/374 CSC, 600 Highland Avenue, Madison, WI 53792-3252, USA.
出版信息
Magn Reson Imaging Clin N Am. 2010 Aug;18(3):337-57, ix. doi: 10.1016/j.mric.2010.08.013.
Abstract
Intracellular fat accumulation is common feature of liver disease. Intracellular fat (steatosis) is the histologic hallmark of nonalcoholic fatty liver disease but also may occur with alcohol abuse, viral hepatitis, HIV and genetic lipodystrophies, and chemotherapy. This article reviews emerging MR imaging techniques that attempt to quantify liver fat. The content provides an overview of fatty liver disease and diseases where fat is an important disease feature. Also discussed is the current use and limitation of nontargeted biopsy in diffuse liver disease and why quantitative noninvasive biomarkers of liver fat would be beneficial.
摘要
细胞内脂肪堆积是肝脏疾病的常见特征。细胞内脂肪（脂肪变性）是非酒精性脂肪性肝病的组织学标志，但也可能发生于酒精滥用、病毒性肝炎、HIV感染、遗传性脂肪营养不良以及化疗过程中。本文综述了旨在定量肝脏脂肪的新兴磁共振成像技术。内容概述了脂肪性肝病以及脂肪作为重要疾病特征的疾病。还讨论了非靶向活检在弥漫性肝病中的当前应用及局限性，以及为什么肝脏脂肪的定量非侵入性生物标志物会有益处。
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本文引用的文献
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J Magn Reson Imaging. 2009 Nov;30(5):1215-22. doi: 10.1002/jmri.21957.
2
Treatment of nonalcoholic fatty liver disease in children: TONIC trial design.儿童非酒精性脂肪性肝病的治疗：TONIC 试验设计。
Contemp Clin Trials. 2010 Jan;31(1):62-70. doi: 10.1016/j.cct.2009.09.001. Epub 2009 Sep 15.
3
Exposure to low-dose ionizing radiation from medical imaging procedures.因医学成像检查而接触低剂量电离辐射。
N Engl J Med. 2009 Aug 27;361(9):849-57. doi: 10.1056/NEJMoa0901249.
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J Hepatol. 2009 Aug;51(2):389-97. doi: 10.1016/j.jhep.2009.04.012. Epub 2009 May 18.
5
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