Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Curr Opin Cell Biol. 2011 Feb;23(1):71-7. doi: 10.1016/j.ceb.2010.10.013. Epub 2010 Nov 20.
Many recent studies have revealed exquisite subcellular localization of proteins, DNA, and other molecules within bacterial cells, giving credence to the concept of prokaryotic anatomy. Common sites for localized components are the poles of rod-shaped cells, which are dynamically modified in composition and function in order to control cellular physiology. An impressively diverse array of mechanisms underlies bacterial polarity, including oscillatory systems, phospho-signaling pathways, the sensing of membrane curvature, and the integration of cell cycle regulators with polar maturation.
许多近期的研究揭示了细菌细胞内蛋白质、DNA 和其他分子的精细亚细胞定位，这为原核生物的解剖学概念提供了依据。局部成分的常见位置是杆状细胞的两极，两极的组成和功能在不断变化，以控制细胞的生理机能。细菌极性的基础是一系列令人印象深刻的多样化机制，包括振荡系统、磷酸信号通路、膜曲率的感应以及细胞周期调节剂与极性成熟的整合。
