用于生物控制应用的实时实验界面。
Real-time experiment interface for biological control applications.
作者信息
Lin Risa J, Bettencourt Jonathan, Wha Ite John, Christini David J, Butera Robert J
机构信息
Georgia Institute of Technology, Atlanta, GA 30332-0250, USA.
出版信息
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:4160-3. doi: 10.1109/IEMBS.2010.5627397.
Abstract
The Real-time Experiment Interface (RTXI) is a fast and versatile real-time biological experimentation system based on Real-Time Linux. RTXI is open source and free, can be used with an extensive range of experimentation hardware, and can be run on Linux or Windows computers (when using the Live CD). RTXI is currently used extensively for two experiment types: dynamic patch clamp and closed-loop stimulation pattern control in neural and cardiac single cell electrophysiology. RTXI includes standard plug-ins for implementing commonly used electrophysiology protocols with synchronized stimulation, event detection, and online analysis. These and other user-contributed plug-ins can be found on the website (http://www.rtxi.org).
摘要
实时实验接口（RTXI）是一个基于实时Linux的快速且通用的实时生物实验系统。RTXI是开源且免费的，可与广泛的实验硬件配合使用，并且可以在Linux或Windows计算机上运行（使用Live CD时）。RTXI目前广泛应用于两种实验类型：神经和心脏单细胞电生理学中的动态膜片钳和闭环刺激模式控制。RTXI包括用于通过同步刺激、事件检测和在线分析来实现常用电生理协议的标准插件。这些以及其他用户贡献的插件可在网站（http://www.rtxi.org）上找到。
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本文引用的文献
1
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Biophys J. 2009 Nov 18;97(10):2684-92. doi: 10.1016/j.bpj.2009.09.002.
2
Dynamical mechanism for subcellular alternans in cardiac myocytes.心肌细胞亚细胞交替变化的动力学机制。
Circ Res. 2009 Aug 14;105(4):335-42. doi: 10.1161/CIRCRESAHA.109.197590. Epub 2009 Jul 23.
3
Effects of imperfect dynamic clamp: computational and experimental results.非理想动态钳制的影响：计算与实验结果
J Neurosci Methods. 2008 Apr 30;169(2):282-9. doi: 10.1016/j.jneumeth.2007.10.009. Epub 2007 Oct 24.
4
Behavioural improvements with thalamic stimulation after severe traumatic brain injury.重度创伤性脑损伤后丘脑刺激带来的行为改善
Nature. 2007 Aug 2;448(7153):600-3. doi: 10.1038/nature06041.
5
Control of electrical alternans in canine cardiac purkinje fibers.犬心脏浦肯野纤维电交替的控制
Phys Rev Lett. 2006 Mar 17;96(10):104101. doi: 10.1103/PhysRevLett.96.104101.
6
MRCI: a flexible real-time dynamic clamp system for electrophysiology experiments.MRCI：一种用于电生理实验的灵活实时动态钳系统。
J Neurosci Methods. 2004 Jan 30;132(2):109-23. doi: 10.1016/j.jneumeth.2003.08.002.
7
Real-Time linux dynamic clamp: a fast and flexible way to construct virtual ion channels in living cells.实时Linux动态钳制：在活细胞中构建虚拟离子通道的快速灵活方法。
Ann Biomed Eng. 2001 Oct;29(10):897-907. doi: 10.1114/1.1408929.
8
A methodology for achieving high-speed rates for artificial conductance injection in electrically excitable biological cells.一种在电可兴奋生物细胞中实现人工电导注入高速率的方法。
IEEE Trans Biomed Eng. 2001 Dec;48(12):1460-70. doi: 10.1109/10.966605.
9
The NEURON simulation environment.NEURON模拟环境。
Neural Comput. 1997 Aug 15;9(6):1179-209. doi: 10.1162/neco.1997.9.6.1179.
10
Controlling chaos in the brain.控制大脑中的混沌状态。
Nature. 1994 Aug 25;370(6491):615-20. doi: 10.1038/370615a0.
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