Shepherd J, Packard C J, Patsch J R, Gotto A M, Taunton O D
Eur J Clin Invest. 1978 Jun;8(3):115-20. doi: 10.1111/j.1365-2362.1978.tb00823.x.
Rate zonal ultracentrifugation of plasma samples from ten healthy age-matched volunteers (five males, five females) indicated that the high density lipoprotein subfraction ratio (HDL2:HDL3) in females was significantly higher than in males. The cause of this phenomenon was investigated by simultaneous examination of the metabolism of the major HDL apoproteins (apoA-I and apoA-II) in both groups. The results show that there is no significant sex-related difference in the plasma pool size, fractional catabolic rate, or synthetic rate of either apoprotein. We conclude that the increased HDL2:HDL3 ratio in femalse versus males does not derive from measurable differences in the metabolic handling of either apoprotein.
对十名年龄匹配的健康志愿者（五名男性，五名女性）的血浆样本进行速率区带超速离心，结果表明女性的高密度脂蛋白亚组分比例（HDL2:HDL3）显著高于男性。通过同时检测两组主要HDL载脂蛋白（载脂蛋白A-I和载脂蛋白A-II）的代谢情况来研究这一现象的原因。结果显示，两种载脂蛋白的血浆池大小、分解代谢率或合成率均无显著的性别差异。我们得出结论，女性与男性相比HDL2:HDL3比例升高并非源于任何一种载脂蛋白在代谢处理上的可测量差异。
