Okulov V B, Anisimov V N, Chepik O F
Exp Pathol. 1981;20(1):1-5. doi: 10.1016/s0232-1513(81)80002-3.
The effect of epidermal or liver G1 and G2 chalone-containing extracts (CCE), prepared from rat skin and liver, upon DMBA-induced carcinogenesis in the vagina of BALB/c mice was studied. One per cent solutions of CCE in PBS were administered intravaginally on polyurethane sponges twice a week during the course of intravaginal applications of DMBA or after its completion up to the death of mice. When administered during te course of DMBA treatment, skin CCE prolonged the latency of cervicovaginal tumours in comparison with liver CCE (48.0 +/- 0.37 and 44.8 +/- 0.54 days, respectively; p less than 0.05). When administered after the course of DMBA application, skin CCE prolonged the lifespan of mice bearing cervicovaginal squamous cell carcinomas in comparison with liver CCE (192 +/- 12.3 and 161 +/- 9.0 days, respectively; p less than 0.05). Skin CCE did not possess any general toxic effect on mice and they were bearing CCE applications for a rather a long period without visible side effects.
研究了从大鼠皮肤和肝脏制备的含表皮或肝脏G1和G2抑素提取物（CCE）对BALB/c小鼠阴道中DMBA诱导致癌作用的影响。在阴道内应用DMBA的过程中或应用完成后直至小鼠死亡，每周两次将CCE在PBS中的1%溶液通过聚氨酯海绵经阴道给药。当在DMBA治疗过程中给药时，与肝脏CCE相比，皮肤CCE延长了宫颈阴道肿瘤的潜伏期（分别为48.0±0.37天和44.8±0.54天；p<0.05）。当在DMBA应用过程之后给药时，与肝脏CCE相比，皮肤CCE延长了患有宫颈阴道鳞状细胞癌小鼠的寿命（分别为192±12.3天和161±9.0天；p<0.05）。皮肤CCE对小鼠没有任何一般毒性作用，并且它们长时间接受CCE给药而没有明显的副作用。
