Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX 77555-1102, USA.
Sci Transl Med. 2010 Nov 24;2(59):59ps54. doi: 10.1126/scitranslmed.3000721.
Translational research on endogenous gaseous mediators--nitric oxide, carbon monoxide, and hydrogen sulfide--has exploded over the past decade. Drugs that modulate either the gaseous mediators themselves or their related intracellular signaling pathways are already in use in the clinics, and still more are being tested in preclinical models and clinical trials. Discussed here are the chemical and pharmacological properties that present challenges for the translation of these potentially toxic molecules.
在过去的十年中，内源性气态介质（一氧化氮、一氧化碳和硫化氢）的转化研究呈爆炸式增长。调节气态介质本身或其相关细胞内信号通路的药物已经在临床上使用，还有更多的药物正在临床前模型和临床试验中进行测试。本文讨论了这些潜在有毒分子转化所面临的化学和药理学性质的挑战。
