调节性 T 细胞-IgA 轴在与微生物组维持宿主免疫稳态中的作用。
Treg cell-IgA axis in maintenance of host immune homeostasis with microbiota.
机构信息
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-1019, USA.
出版信息
Int Immunopharmacol. 2011 May;11(5):589-92. doi: 10.1016/j.intimp.2010.11.016. Epub 2010 Nov 24.
Abstract
The intestine is the home to a vast diversity of microbiota and a complex of mucosal immune system. Multiple regulatory mechanisms control host immune responses to microbiota and maintain intestinal immune homeostasis. This mini review will provide evidence indicating a Treg cell-IgA axis and such axis playing a major role in maintenance of intestinal homeostasis.
摘要
肠道是一个拥有大量微生物群落和复杂黏膜免疫系统的家园。多种调控机制控制着宿主对微生物群的免疫反应，并维持肠道免疫稳态。这篇综述提供了证据表明 Treg 细胞-IgA 轴在维持肠道稳态中起着重要作用。
相似文献
1
Treg cell-IgA axis in maintenance of host immune homeostasis with microbiota.调节性 T 细胞-IgA 轴在与微生物组维持宿主免疫稳态中的作用。
Int Immunopharmacol. 2011 May;11(5):589-92. doi: 10.1016/j.intimp.2010.11.016. Epub 2010 Nov 24.
2
A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota.对肠道微生物群的显性、协调性调节性T细胞-IgA反应。
Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19256-61. doi: 10.1073/pnas.0812681106. Epub 2009 Nov 4.
3
The continuum of intestinal CD4+ T cell adaptations in host-microbial mutualism.宿主-微生物共生中肠道 CD4+T 细胞适应性的连续统
Gut Microbes. 2011 Nov-Dec;2(6):353-7. doi: 10.4161/gmic.18604. Epub 2011 Nov 1.
4
Adaptive immunity in the host-microbiota dialog.宿主-微生物群对话中的适应性免疫。
Mucosal Immunol. 2011 Jan;4(1):15-21. doi: 10.1038/mi.2010.60. Epub 2010 Oct 13.
5
c-Maf-dependent T cell control of intestinal T17 cells and IgA establishes host-microbiota homeostasis.c-Maf 依赖性 T 细胞控制肠道 T17 细胞和 IgA 从而建立宿主-微生物群的稳态。
Nat Immunol. 2019 Apr;20(4):471-481. doi: 10.1038/s41590-019-0316-2. Epub 2019 Feb 18.
6
Immunoregulation by the gut microbiota.肠道微生物群的免疫调节。
Cell Mol Life Sci. 2012 Nov;69(21):3635-50. doi: 10.1007/s00018-012-0993-6. Epub 2012 Apr 22.
7
Induction of Treg cells in the mouse colonic mucosa: a central mechanism to maintain host-microbiota homeostasis.诱导小鼠结肠黏膜中的 Treg 细胞：维持宿主-微生物群平衡的核心机制。
Semin Immunol. 2012 Feb;24(1):50-7. doi: 10.1016/j.smim.2011.11.009. Epub 2011 Dec 14.
8
[The intestinal microbiota and inflammatory bowel disease].[肠道微生物群与炎症性肠病]
Gastroenterol Hepatol. 2011 Mar;34(3):147-54. doi: 10.1016/j.gastrohep.2010.11.009. Epub 2011 Mar 5.
9
Follicular helper T cell-mediated mucosal barrier maintenance.滤泡辅助性T细胞介导的黏膜屏障维持。
Immunol Lett. 2014 Dec;162(2 Pt A):39-47. doi: 10.1016/j.imlet.2014.07.015. Epub 2014 Aug 19.
10
CBirTox is a selective antigen-specific agonist of the Treg-IgA-microbiota homeostatic pathway.CBirTox是Treg-IgA-微生物群稳态途径的一种选择性抗原特异性激动剂。
PLoS One. 2017 Jul 27;12(7):e0181866. doi: 10.1371/journal.pone.0181866. eCollection 2017.
引用本文的文献
1
Microbiota activation and regulation of adaptive immunity.微生物组激活与适应性免疫调节。
Front Immunol. 2024 Oct 9;15:1429436. doi: 10.3389/fimmu.2024.1429436. eCollection 2024.
2
Regulatory T and B cells in pediatric Henoch-Schönlein purpura: friends or foes?儿童过敏性紫癜中调节性 T 和 B 细胞：是敌是友？
Arthritis Res Ther. 2024 Feb 16;26(1):52. doi: 10.1186/s13075-024-03278-w.
3
B Cells in Breast Cancer Pathology.乳腺癌病理学中的B细胞
Cancers (Basel). 2023 Feb 28;15(5):1517. doi: 10.3390/cancers15051517.
4
Pyruvate: Ferredoxin oxidoreductase is involved in IgA-related microbiota dysbiosis and intestinal inflammation.丙酮酸：铁氧还蛋白氧化还原酶与 IgA 相关的微生物失调和肠道炎症有关。
Front Immunol. 2022 Dec 7;13:1040774. doi: 10.3389/fimmu.2022.1040774. eCollection 2022.
5
Human umbilical cord mesenchymal stem cells regulate immunoglobulin a secretion and remodel the diversification of intestinal microbiota to improve colitis.人脐带间充质干细胞调节免疫球蛋白 A 的分泌并重塑肠道微生物群的多样化以改善结肠炎。
Front Cell Infect Microbiol. 2022 Sep 2;12:960208. doi: 10.3389/fcimb.2022.960208. eCollection 2022.
6
Biomarkers in oral immunotherapy.口腔免疫治疗中的生物标志物。
J Zhejiang Univ Sci B. 2022;23(9):705-731. doi: 10.1631/jzus.B2200047.
7
The impact of the Th17:Treg axis on the IgA-Biome across the glycemic spectrum.Th17:Treg 轴在血糖谱范围内对 IgA 生物群的影响。
PLoS One. 2021 Oct 20;16(10):e0258812. doi: 10.1371/journal.pone.0258812. eCollection 2021.
8
Mucosal immunity to poliovirus.肠道黏膜对脊髓灰质炎病毒的免疫。
Mucosal Immunol. 2022 Jan;15(1):1-9. doi: 10.1038/s41385-021-00428-0. Epub 2021 Jul 8.
9
Coordinated co-migration of CCR10 antibody-producing B cells with helper T cells for colonic homeostatic regulation.CCR10 抗体产生 B 细胞与辅助性 T 细胞的协调共迁移，以调节结肠的稳态。
Mucosal Immunol. 2021 Mar;14(2):420-430. doi: 10.1038/s41385-020-0333-3. Epub 2020 Aug 9.
10
Short-Term Amoxicillin-Induced Perturbation of the Gut Microbiota Promotes Acute Intestinal Immune Regulation in Brown Norway Rats.短期阿莫西林诱导的肠道微生物群扰动促进棕色挪威大鼠的急性肠道免疫调节。
Front Microbiol. 2020 Mar 26;11:496. doi: 10.3389/fmicb.2020.00496. eCollection 2020.
本文引用的文献
1
Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses.无菌小鼠可发生可逆转的微生物定殖，揭示 IgA 免疫应答的动态变化。
Science. 2010 Jun 25;328(5986):1705-9. doi: 10.1126/science.1188454.
2
Immunology. IgA changes the rules of memory.免疫学。免疫球蛋白A改变记忆规则。
Science. 2010 Jun 25;328(5986):1646-7. doi: 10.1126/science.1192488.
3
Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis.肠道中的适应性免疫调节：T 细胞依赖性和 T 细胞非依赖性 IgA 合成。
Annu Rev Immunol. 2010;28:243-73. doi: 10.1146/annurev-immunol-030409-101314.
4
Immune adaptations that maintain homeostasis with the intestinal microbiota.与肠道微生物群维持体内平衡的免疫适应。
Nat Rev Immunol. 2010 Mar;10(3):159-69. doi: 10.1038/nri2710.
5
A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota.对肠道微生物群的显性、协调性调节性T细胞-IgA反应。
Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19256-61. doi: 10.1073/pnas.0812681106. Epub 2009 Nov 4.
6
Regulatory T cells reinforce intestinal homeostasis.调节性T细胞加强肠道内稳态。
Immunity. 2009 Sep 18;31(3):401-11. doi: 10.1016/j.immuni.2009.08.011.
7
The multifaceted influence of the mucosal microflora on mucosal dendritic cell responses.黏膜微生物群对黏膜树突状细胞反应的多方面影响。
Immunity. 2009 Sep 18;31(3):377-88. doi: 10.1016/j.immuni.2009.09.001.
8
Diverse regulatory pathways for IgA synthesis in the gut.肠道中IgA合成的多种调节途径。
Mucosal Immunol. 2009 Nov;2(6):468-71. doi: 10.1038/mi.2009.107. Epub 2009 Sep 9.
9
Regulatory lymphocytes and intestinal inflammation.调节性淋巴细胞与肠道炎症
Annu Rev Immunol. 2009;27:313-38. doi: 10.1146/annurev.immunol.021908.132657.
10
The immune geography of IgA induction and function.IgA诱导与功能的免疫地理学
Mucosal Immunol. 2008 Jan;1(1):11-22. doi: 10.1038/mi.2007.6.
Zotero 插件