乙肝e抗原和抗体在坏死性肝硬化及原发性肝细胞癌中的发生率及意义
Incidence and significance of hepatitis B e antigen and antibody in postnecrotic cirrhosis and primary hepatocellular carcinoma.
作者信息
Coursaget P, Maupas P, Goudeau A, Drucker J
出版信息
J Clin Microbiol. 1978 Apr;7(4):394-5. doi: 10.1128/jcm.7.4.394-395.1978.
Abstract
A study of the serological markers of Hepatitis B virus (HBV) including e antigen (HBe Ag) and antibody against HBe Ag (anti-HBe) was performed in Senegalese patients suffering from cirrhosis and primary hepatocellular carcinoma, and in a control group (blood donors). It was not possible to diagnose additional HBV infections in primary hepatocellular carcinoma patients using HBe Ag or anti-HBe Ab alone as serological markers. The lower prevalence of HBe Ag among primary hepatocellular carcinoma patients as compared with cirrhotic patients suggests that active replication of HBV becomes increasingly defective during the course of the malignant process.
摘要
对患有肝硬化和原发性肝细胞癌的塞内加尔患者以及对照组（献血者）进行了一项关于乙肝病毒（HBV）血清学标志物的研究，这些标志物包括e抗原（HBe Ag）和抗HBe抗原抗体（抗-HBe）。仅使用HBe Ag或抗-HBe抗体作为血清学标志物，无法诊断原发性肝细胞癌患者中的额外HBV感染。与肝硬化患者相比，原发性肝细胞癌患者中HBe Ag的患病率较低，这表明在恶性过程中，HBV的活跃复制越来越有缺陷。
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