Kumazawa N H, Yoshikawa M
J Hyg (Lond). 1978 Aug;81(1):15-23. doi: 10.1017/s0022172400053729.
The epidemiological and drug susceptibility data on whooping cough suggested a possibility that Bordetella pertussis converts in some way to Bordetella parapertussis. To prove this, B. pertussis strain 75 was treated with N-methyl-N'-nitro-N-nitrosoguanidine and a mutant resistant to staphcillin v and eight mutants resistant to trimethoprim were isolated. The staphcillin V-resistant mutant of B. pertussis agreed with all of the criteria of B. parapertussis and the trimethoprim-resistant mutants also agreed with many of these criteria. Thus, a hypothesis is presented that B. parapertussis is a mutant of B. pertussis which appeared in nature probably by a selective pressure of antibiotics.
关于百日咳的流行病学和药敏数据表明，百日咳博德特氏菌有可能以某种方式转变为副百日咳博德特氏菌。为了证实这一点，用N-甲基-N'-硝基-N-亚硝基胍处理百日咳博德特氏菌菌株75，分离出一株对苯唑西林V耐药的突变体和八株对甲氧苄啶耐药的突变体。百日咳博德特氏菌的苯唑西林V耐药突变体符合副百日咳博德特氏菌的所有标准，甲氧苄啶耐药突变体也符合其中许多标准。因此，提出了一个假说，即副百日咳博德特氏菌是百日咳博德特氏菌的一个突变体，它可能是在抗生素的选择压力下在自然界中出现的。
