HLA-G 在免疫和造血中的作用。
The role of HLA-G in immunity and hematopoiesis.
机构信息
CEA, I2BM, Service de Recherches en Hemato-Immunologie, 75475 Paris, France.
出版信息
Cell Mol Life Sci. 2011 Feb;68(3):353-68. doi: 10.1007/s00018-010-0579-0. Epub 2010 Nov 30.
Abstract
The non-classical HLA class I molecule HLA-G was initially shown to play a major role in feto-maternal tolerance. Since this discovery, it has been established that HLA-G is a tolerogenic molecule which participates to the control of the immune response. In this review, we summarize the recent advances on (1) the multiple structures of HLA-G, which are closely associated with their role in the inhibition of NK cell cytotoxicity, (2) the factors that regulate the expression of HLA-G and its receptors, (3) the mechanism of action of HLA-G at the immunological synapse and through trogocytosis, and (4) the generation of suppressive cells through HLA-G. Moreover, we also review recent findings on the non-immunological functions of HLA-G in erythropoiesis and angiogenesis.
摘要
非经典 HLA I 类分子 HLA-G 最初被证明在胎母免疫耐受中起主要作用。自这一发现以来，已经确定 HLA-G 是一种耐受原性分子，参与控制免疫反应。在这篇综述中，我们总结了 HLA-G 的（1）多种结构，这些结构与它抑制 NK 细胞细胞毒性的作用密切相关，（2）调节 HLA-G 及其受体表达的因素，（3）HLA-G 在免疫突触和通过胞饮作用发挥作用的机制，以及（4）通过 HLA-G 产生抑制性细胞的机制等方面的最新进展。此外，我们还回顾了 HLA-G 在红细胞生成和血管生成中的非免疫功能的最新发现。
相似文献
1
The role of HLA-G in immunity and hematopoiesis.HLA-G 在免疫和造血中的作用。
Cell Mol Life Sci. 2011 Feb;68(3):353-68. doi: 10.1007/s00018-010-0579-0. Epub 2010 Nov 30.
2
HLA-G: on the track of immunological functions.HLA-G：探寻免疫功能之路
Eur J Immunogenet. 1997 Oct;24(5):397-408. doi: 10.1046/j.1365-2370.1997.d01-109.x.
3
HLA-G expression in malignant melanoma.恶性黑色素瘤中的HLA - G表达
Semin Cancer Biol. 2007 Dec;17(6):422-9. doi: 10.1016/j.semcancer.2007.06.010. Epub 2007 Jun 28.
4
HLA-G expression in cancers: potential role in diagnosis, prognosis and therapy.人类白细胞抗原-G在癌症中的表达：在诊断、预后和治疗中的潜在作用。
Endocr Metab Immune Disord Drug Targets. 2011 Mar;11(1):76-89. doi: 10.2174/187153011794982059.
5
HLA-G molecules: from maternal-fetal tolerance to tissue acceptance.人类白细胞抗原-G分子：从母胎耐受到组织接受
Adv Immunol. 2003;81:199-252. doi: 10.1016/s0065-2776(03)81006-4.
6
[HLA-G: an immunoregulatory non classical class I HLA molecule].[人类白细胞抗原-G：一种免疫调节性非经典I类人类白细胞抗原分子]
Arch Inst Pasteur Tunis. 2009;86(1-4):27-38.
7
HLA-G in organ transplantation: towards clinical applications.HLA-G 在器官移植中的作用：迈向临床应用。
Cell Mol Life Sci. 2011 Feb;68(3):397-404. doi: 10.1007/s00018-010-0581-6. Epub 2010 Nov 20.
8
Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association.HLA-G 多态性对其功能、调节、进化和疾病关联的影响。
Cell Mol Life Sci. 2011 Feb;68(3):369-95. doi: 10.1007/s00018-010-0580-7. Epub 2010 Nov 24.
9
[The role of HLA-G expression in the embryo during implantation].[HLA-G表达在胚胎着床过程中的作用]
J Gynecol Obstet Biol Reprod (Paris). 2004 Feb;33(1 Pt 2):S9-12. doi: 10.1016/s0368-2315(04)96396-x.
10
HLA-G and inflammatory diseases.人类白细胞抗原-G与炎症性疾病。
Inflamm Allergy Drug Targets. 2008 Jun;7(2):67-74. doi: 10.2174/187152808785107615.
引用本文的文献
1
Uncovering biomarkers and pathways in oral squamous cell carcinoma through integrated lncRNA-mRNA regulatory network analysis.通过整合lncRNA-mRNA调控网络分析揭示口腔鳞状细胞癌中的生物标志物和信号通路
Discov Oncol. 2025 Aug 4;16(1):1462. doi: 10.1007/s12672-025-02922-4.
2
The Multifaced Actions of Curcumin in Pregnancy Outcome.姜黄素对妊娠结局的多方面作用
Antioxidants (Basel). 2021 Jan 17;10(1):126. doi: 10.3390/antiox10010126.
3
Puzzling out the COVID-19: Therapy targeting HLA-G and HLA-E.破解 COVID-19 之谜：针对 HLA-G 和 HLA-E 的治疗方法。
Hum Immunol. 2020 Dec;81(12):697-701. doi: 10.1016/j.humimm.2020.10.001. Epub 2020 Oct 7.
4
Therapeutic Mesenchymal Stromal Cells for Immunotherapy and for Gene and Drug Delivery.用于免疫治疗以及基因和药物递送的治疗性间充质基质细胞
Mol Ther Methods Clin Dev. 2020 Jan 22;16:204-224. doi: 10.1016/j.omtm.2020.01.005. eCollection 2020 Mar 13.
5
Heterogeneity of HLA-G Expression in Cancers: Facing the Challenges.HLA-G 在癌症中的表达异质性：应对挑战。
Front Immunol. 2018 Sep 27;9:2164. doi: 10.3389/fimmu.2018.02164. eCollection 2018.
6
The Folate Cycle As a Cause of Natural Killer Cell Dysfunction and Viral Etiology in Type 1 Diabetes.叶酸循环作为1型糖尿病中自然杀伤细胞功能障碍和病毒病因的一个原因。
Front Endocrinol (Lausanne). 2017 Nov 23;8:315. doi: 10.3389/fendo.2017.00315. eCollection 2017.
7
Role of major histocompatibility complex variation in graft-versus-host disease after hematopoietic cell transplantation.主要组织相容性复合体变异在造血细胞移植后移植物抗宿主病中的作用。
F1000Res. 2017 May 3;6:617. doi: 10.12688/f1000research.10990.1. eCollection 2017.
8
Soluble human leukocyte antigen -G during pregnancy and infancy in Benin: Mother/child resemblance and association with the risk of malaria infection and low birth weight.贝宁孕期和婴儿期的可溶性人类白细胞抗原-G：母婴相似性及其与疟疾感染风险和低出生体重的关联
PLoS One. 2017 Feb 6;12(2):e0171117. doi: 10.1371/journal.pone.0171117. eCollection 2017.
9
The Expanding Role of Natural Killer Cells in Type 1 Diabetes and Immunotherapy.自然杀伤细胞在1型糖尿病和免疫治疗中不断扩大的作用
Curr Diab Rep. 2016 Nov;16(11):109. doi: 10.1007/s11892-016-0806-7.
10
Transcriptomics: A Step behind the Comprehension of the Polygenic Influence on Oxidative Stress, Immune Deregulation, and Mitochondrial Dysfunction in Chronic Kidney Disease.转录组学：对慢性肾脏病氧化应激、免疫失调和线粒体功能障碍的多基因影响理解的滞后。
Biomed Res Int. 2016;2016:9290857. doi: 10.1155/2016/9290857. Epub 2016 Jun 21.
本文引用的文献
1
Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway.1 型调节性 T 细胞（Tr1）的分化由耐受型 DC-10 通过依赖于 IL-10 的 ILT4/HLA-G 途径实现。
Blood. 2010 Aug 12;116(6):935-44. doi: 10.1182/blood-2009-07-234872. Epub 2010 May 6.
2
Different functional outcomes of intercellular membrane transfers to monocytes and T cells.细胞间膜向单核细胞和 T 细胞转移的不同功能结果。
Cell Mol Life Sci. 2010 Apr;67(7):1133-45. doi: 10.1007/s00018-009-0239-4.
3
Haematopoietic stem cells derive directly from aortic endothelium during development.造血干细胞在发育过程中直接来源于主动脉内皮。
Nature. 2010 Mar 4;464(7285):108-11. doi: 10.1038/nature08738. Epub 2010 Feb 14.
4
Blood stem cells emerge from aortic endothelium by a novel type of cell transition.血液干细胞通过一种新型的细胞转变从主动脉内皮中出现。
Nature. 2010 Mar 4;464(7285):112-5. doi: 10.1038/nature08761. Epub 2010 Feb 14.
5
In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium.从鼠主动脉内皮细胞中出现的造血细胞的体内成像。
Nature. 2010 Mar 4;464(7285):116-20. doi: 10.1038/nature08764. Epub 2010 Feb 14.
6
HLA-G expression in human breast cancer: implications for diagnosis and prognosis, and effect on allocytotoxic lymphocyte response after hormone treatment in vitro.人类乳腺癌中 HLA-G 的表达：对诊断和预后的影响，以及对体外激素治疗后细胞毒性淋巴细胞反应的影响。
Ann Surg Oncol. 2010 May;17(5):1459-69. doi: 10.1245/s10434-009-0891-9. Epub 2010 Jan 6.
7
Recent advances on the non-classical major histocompatibility complex class I HLA-G molecule.非经典主要组织相容性复合体I类HLA - G分子的最新进展
Tissue Antigens. 2010 Mar;75(3):201-6. doi: 10.1111/j.1399-0039.2009.01438.x. Epub 2009 Dec 30.
8
Dendritic cells secrete the immunosuppressive HLA-G molecule upon CTLA4-Ig treatment: implication in human renal transplant acceptance.树突状细胞在CTLA4-Ig治疗后分泌免疫抑制性HLA-G分子：对人类肾移植接受的影响
J Immunol. 2009 Dec 1;183(11):7054-62. doi: 10.4049/jimmunol.0803054. Epub 2009 Nov 13.
9
The Tregs' world according to GARP.根据 GARP，调节性 T 细胞的世界。
Eur J Immunol. 2009 Dec;39(12):3296-300. doi: 10.1002/eji.200940117.
10
Progesterone in pregnancy; receptor-ligand interaction and signaling pathways.妊娠中的孕激素；受体-配体相互作用和信号通路。
J Reprod Immunol. 2009 Dec;83(1-2):60-4. doi: 10.1016/j.jri.2009.06.262. Epub 2009 Oct 31.
Zotero 插件