School of Psychology, Queen's University, Belfast, 18-30 Malone Road, Belfast BT9 5BP, UK.
Br J Nutr. 2011 Apr;105(8):1145-9. doi: 10.1017/S0007114510004861. Epub 2010 Dec 6.
Previous research suggests that n-3 PUFA may play a role in bone health. The present analysis aimed to investigate the impact of n-3 PUFA supplementation on bone resorption in adult men and women. Serum samples from 113 mild-moderately depressed individuals (twenty-six males and eighty-seven females, aged 18-67 years) randomised to receive 1·48 g EPA+DHA/d (n 53) or placebo (n 60) for 12 weeks as part of a large recent randomised controlled trial were assayed for n-3 PUFA status and a bone resorption marker, C-terminal cross-linking telopeptide of type 1 collagen (β-CTX). Regression analyses revealed that n-3 PUFA status following supplementation was associated with randomisation (placebo/n-3 PUFA) (B = 3·25, 95 % CI 2·60, 3·91, P < 0·01). However, β-CTX status following supplementation was not associated with randomisation (B = - 0·01, 95 % CI - 0·03, 0·04). Change in β-CTX status was also not associated with change in n-3 PUFA status (B = - 0·002, 95 % CI - 0·01, 0·01). These findings provide no evidence for an association between n-3 PUFA supplementation (1·48 g EPA+DHA/d) for 12 weeks and bone resorption in humans assessed by β-CTX, and suggest that n-3 PUFA supplementation may be unlikely to be of benefit in preventing bone loss.
先前的研究表明，n-3 多不饱和脂肪酸可能在骨骼健康中发挥作用。本分析旨在研究 n-3 多不饱和脂肪酸补充对成年男女骨吸收的影响。113 名轻度至中度抑郁个体（26 名男性和 87 名女性，年龄 18-67 岁）的血清样本，他们随机分配接受 1.48g EPA+DHA/d（n=53）或安慰剂（n=60），作为最近一项大型随机对照试验的一部分，接受为期 12 周的治疗，用于测定 n-3 多不饱和脂肪酸状况和骨吸收标志物 1 型胶原 C 末端交联肽（β-CTX）。回归分析显示，补充后的 n-3 多不饱和脂肪酸状况与随机分组（安慰剂/n-3 多不饱和脂肪酸）相关（B=3.25，95%CI 2.60，3.91，P<0.01）。然而，补充后的 β-CTX 状况与随机分组无关（B=-0.01，95%CI-0.03，0.04）。β-CTX 状况的变化也与 n-3 多不饱和脂肪酸状况的变化无关（B=-0.002，95%CI-0.01，0.01）。这些发现没有提供证据表明 n-3 多不饱和脂肪酸补充（1.48g EPA+DHA/d）12 周与β-CTX 评估的人类骨吸收之间存在关联，并表明 n-3 多不饱和脂肪酸补充不太可能有益于预防骨质流失。
