阿法六驳碱 A，来自白饭树的一种新的柠檬苦素。

Aphanamolide A, a new limonoid from Aphanamixis polystachya.

机构信息

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203, People's Republic of China.

出版信息

Org Lett. 2011 Jan 7;13(1):150-3. doi: 10.1021/ol102745h. Epub 2010 Dec 6.

DOI:10.1021/ol102745h

PMID:21133356

Abstract

Two new limonoids, namely aphanamolides A (1) and B (2), were isolated from the seeds of Aphanamixis polystachya . Their structures were established by spectroscopic methods. Aphanamolide A (1) featured an unprecedented carbon skeleton via the formation of a C-3-C-6 bond. Compounds 1 and 2 showed cytotoxic activity against two tumor cell lines.

摘要

从密花八角的种子中分离得到两个新的柠檬苦素类化合物，分别命名为 aphanamolide A（1）和 B（2）。通过波谱方法确定了它们的结构。化合物 1 具有一个前所未有的碳骨架，通过 C-3-C-6 键的形成。化合物 1 和 2 对两种肿瘤细胞系表现出细胞毒性活性。