非药物干预措施对轻度认知障碍患者的疗效。
Effectiveness of nonpharmacological approaches in patients with mild cognitive impairment.
机构信息
Greek Alzheimer Association, Aristotle University, Thessaloniki, Greece.
出版信息
Neurodegener Dis. 2011;8(3):138-45. doi: 10.1159/000320575. Epub 2010 Dec 3.
BACKGROUND
Mild cognitive impairment (MCI) patients are at increased risk of developing dementia. There is a conflict if cognitive interventions can improve cognitive and functional performances in order to delay the development of dementia.
OBJECTIVES
This study aimed to examine the effectiveness of a holistic cognitive rehabilitation program on patients with MCI.
METHODS
The participants, 176 MCI patients with Mini-Mental State Examination = 27.89 (1.73), were classified into 2 groups matched for age, gender, education and cognitive abilities: (1) patients (104) on nonpharmacological therapy and (2) patients (72) on no therapy at all. The effectiveness of the interventions was assessed by neuropsychological evaluation performed at baseline and at the end of the interventions.
RESULTS
Between-group difference in benefit of the experimental group was demonstrated in abilities of executive function (p = 0.004), verbal memory (p = 0.003), praxis (p ≤ 0.012), daily function (p = 0.001) and general cognitive ability (p ≤ 0.005). The experimental patients improved cognitive and functional performances, while the control patients demonstrated deterioration in daily function (p = 0.004).
CONCLUSIONS
Our findings indicate that nonpharmacological therapy of the holistic approach can improve MCI patients' cognitive and functional performances.
背景
轻度认知障碍（MCI）患者发生痴呆的风险增加。认知干预是否能改善认知和功能表现，从而延缓痴呆的发展，存在争议。
目的
本研究旨在检验整体认知康复方案对 MCI 患者的有效性。
方法
参与者为 176 名 MMSE 评分为 27.89（1.73）的 MCI 患者，按年龄、性别、教育和认知能力分为 2 组：（1）非药物治疗组（104 例），（2）未治疗组（72 例）。在基线和干预结束时进行神经心理学评估，以评估干预的效果。
结果
实验组在执行功能（p = 0.004）、言语记忆（p = 0.003）、执行（p ≤ 0.012）、日常功能（p = 0.001）和总体认知能力（p ≤ 0.005）方面的获益存在组间差异。实验组患者的认知和功能表现得到改善，而对照组患者的日常功能恶化（p = 0.004）。
结论
我们的研究结果表明，整体方法的非药物治疗可以改善 MCI 患者的认知和功能表现。
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