Department of Immunology and Microbial Science, SP30-2110, The Scripps Research Institute, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, USA.
Eur J Neurosci. 2011 Jan;33(2):197-204. doi: 10.1111/j.1460-9568.2010.07500.x. Epub 2010 Dec 7.
Autophagy is emerging as a central regulator of cellular health and disease and, in the central nervous system (CNS), this homeostatic process appears to influence synaptic growth and plasticity. Herein, we review the evidence that dysregulation of autophagy may contribute to several neurodegenerative diseases of the CNS. Up-regulation of autophagy may prevent, delay or ameliorate at least some of these disorders, and - based on recent findings from our laboratory - we speculate that this goal may be achieved using a safe, simple and inexpensive approach.
自噬正在成为细胞健康和疾病的一个核心调节者，在中枢神经系统（CNS）中，这个内稳态过程似乎影响着突触的生长和可塑性。本文综述了自噬失调可能导致中枢神经系统几种神经退行性疾病的证据。自噬的上调可能预防、延迟或改善至少其中一些疾病，并且——基于我们实验室最近的发现——我们推测，这一目标可以通过一种安全、简单和廉价的方法来实现。
