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人类多形核白细胞对在生物膜中生长的铜绿假单胞菌的反应。

Human polymorphonuclear leukocyte response to Pseudomonas aeruginosa grown in biofilms.

作者信息

Jensen E T, Kharazmi A, Lam K, Costerton J W, Høiby N

机构信息

Department of Clinical Microbiology, Statens Seruminstitut, Copenhagen, Denmark.

出版信息

Infect Immun. 1990 Jul;58(7):2383-5. doi: 10.1128/iai.58.7.2383-2385.1990.

Abstract

The interaction of human neutrophils with Pseudomonas aeruginosa biofilms was examined by using a chemiluminescence assay. The biofilms induced an oxidative burst response by polymorphonuclear leukocytes which was slow and only 25% of the response to planktonic bacteria. The reduced response to P. aeruginosa biofilms could play a role in the persistence of bacteria in chronic infections.

摘要

通过化学发光测定法研究了人类中性粒细胞与铜绿假单胞菌生物膜的相互作用。生物膜诱导多形核白细胞产生氧化爆发反应,该反应缓慢,仅为对浮游细菌反应的25%。对铜绿假单胞菌生物膜反应的降低可能在慢性感染中细菌的持续存在中起作用。

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本文引用的文献

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Opsonin-independent phagocytosis of Pseudomonas aeruginosa.
Antibiot Chemother (1971). 1985;36:88-94. doi: 10.1159/000410474.

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