Macular Pigment Research Group, Department of Chemical and Life Sciences, Waterford Institute of Technology, Waterford, Republic of Ireland.
Br J Nutr. 2011 Apr;105(7):1036-46. doi: 10.1017/S0007114510004721. Epub 2010 Dec 9.
The objective of the present study was to investigate whether weight loss is associated with changes in serum concentrations of lutein (L) and zeaxanthin (Z), and/or macular pigment optical density (MPOD). We recruited 104 overweight subjects into this randomised controlled weight loss study. For the intervention group (I group), weight was assessed weekly and body composition, including BMI (kg/m2) and body fat (kg and percentage), was assessed at baseline, 6 and 12 months. Weight loss was encouraged using dietary and exercise programmes. MPOD was measured by heterochromatic flicker photometry and serum concentrations of L and Z by HPLC (at baseline, 1, 3, 6 and 12 months). The control (C) group was assessed at baseline and 12 months. Repeated-measures ANOVA (RMA) demonstrated significant weight loss in the I group over the study period (P = 0·000). There was no significant weight change in the C group (P = 0·993). RMA of dietary L and Z, serum L and Z, and MPOD demonstrated no significant time or time × group interaction effect in any of these parameters (P>0·05 for all), with the exception of a significant decrease in the dietary intake of Z seen in both groups, over the study period (P < 0·05). There was a positive and significant relationship between body fat loss (kg) and increase in serum concentrations of L in the I group (r 0·521; P = 0·006). Our finding that a reduction in body composition (e.g. fat mass) is related to increases in serum concentrations of L is consistent with the hypothesis that body fat acts as a reservoir for this carotenoid, and that weight loss can positively influence circulating carotenoid levels.
本研究旨在探讨体重减轻是否与叶黄素 (L) 和玉米黄质 (Z) 的血清浓度变化以及/或黄斑色素光学密度 (MPOD) 有关。我们招募了 104 名超重受试者参与这项随机对照减重研究。对于干预组 (I 组)，每周评估体重，基线、6 个月和 12 个月评估身体成分，包括 BMI (kg/m2) 和体脂肪 (kg 和百分比)。通过饮食和运动方案鼓励减重。通过异色相闪烁光度法测量 MPOD，通过 HPLC 测量 L 和 Z 的血清浓度 (基线、1、3、6 和 12 个月)。对照组 (C 组) 仅在基线和 12 个月时进行评估。重复测量方差分析 (RMA) 显示 I 组在研究期间体重明显减轻 (P = 0.000)。C 组体重无显著变化 (P = 0.993)。对饮食 L 和 Z、血清 L 和 Z 以及 MPOD 的 RMA 分析表明，在这些参数中没有观察到时间或时间×组交互作用的显著影响 (所有 P>0.05)，但两个组的 Z 饮食摄入量均显著减少例外 (P<0.05)。在 I 组中，体脂肪损失 (kg) 与血清 L 浓度增加呈正相关 (r 0.521; P = 0.006)。我们发现身体成分 (如脂肪量) 的减少与血清 L 浓度的增加有关，这与身体脂肪作为这种类胡萝卜素的储存库的假说一致，并且体重减轻可以对循环类胡萝卜素水平产生积极影响。
