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一种在神经传导中存在温度敏感阻滞的果蝇突变体。

A Drosophila mutant with a temperature-sensitive block in nerve conduction.

作者信息

Wu C F, Ganetzky B, Jan L Y, Jan Y N, Benzer S

出版信息

Proc Natl Acad Sci U S A. 1978 Aug;75(8):4047-51. doi: 10.1073/pnas.75.8.4047.

DOI:10.1073/pnas.75.8.4047
PMID:211514
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC392928/
Abstract

A mutant, napts (no action potential, temperature-sensitive), is described in which axonal conduction fails at high temperature. Synaptic transmission at the larval neuromuscular junction is unimpaired. Larvae and adults are rapidly paralyzed at restrictive temperatures; they recover rapidly when the temperature is decreased. The mutant gene is recessive and is located on the second chromosome at map position 56.

摘要

描述了一种突变体napts（无动作电位，温度敏感型），其轴突传导在高温下会失效。幼虫神经肌肉接头处的突触传递未受损害。幼虫和成虫在限制温度下会迅速麻痹；当温度降低时，它们会迅速恢复。该突变基因是隐性的，位于第二条染色体的图谱位置56处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/528e/392928/55600c5b3b23/pnas00020-0519-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/528e/392928/cf2d82d5638f/pnas00020-0518-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/528e/392928/55600c5b3b23/pnas00020-0519-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/528e/392928/cf2d82d5638f/pnas00020-0518-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/528e/392928/55600c5b3b23/pnas00020-0519-a.jpg

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