Department of Biochemical and Microbial Technology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.
FEBS J. 2011 Jan;278(2):206-21. doi: 10.1111/j.1742-4658.2010.07949.x. Epub 2010 Dec 13.
Cytochrome P450 monooxygenases (P450s) are a diverse collection of enzymes acting on various endogenous and xenobiotic molecules. Most of them catalyse hydroxylation reactions and one group of possible substrates are fatty acids and their related structures. In this minireview, the significance of P450s in microbial fatty acid conversion is described. Bacteria and yeasts possess various P450 systems involved in alkane and fatty acid degradation, and often several enzymes with different activities and specificities are retrieved in one organism. Furthermore, P450s take part in the formation of fatty acid-based secondary metabolites. Finally, there are a substantial number of microbial P450s displaying activity towards fatty acids, but to which no biological role could be assigned despite the often quite intense research.
细胞色素 P450 单加氧酶（P450s）是作用于各种内源性和外源性分子的多种酶的集合。它们大多数催化羟化反应，而一组可能的底物是脂肪酸及其相关结构。在这篇简评中，描述了 P450s 在微生物脂肪酸转化中的意义。细菌和酵母具有各种参与烷烃和脂肪酸降解的 P450 系统，并且通常在一个生物体中回收具有不同活性和特异性的几种酶。此外，P450s 参与了基于脂肪酸的次生代谢物的形成。最后，有相当数量的微生物 P450s 对脂肪酸表现出活性，但尽管经常进行相当深入的研究，却没有为其分配任何生物学作用。
