The Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.
School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane 4072, Australia.
Nat Prod Rep. 2018 Aug 15;35(8):757-791. doi: 10.1039/c7np00063d.
Covering: 2000 up to 2018 The cytochromes P450 (P450s) are a superfamily of heme-containing monooxygenases that perform diverse catalytic roles in many species, including bacteria. The P450 superfamily is widely known for the hydroxylation of unactivated C-H bonds, but the diversity of reactions that P450s can perform vastly exceeds this undoubtedly impressive chemical transformation. Within bacteria, P450s play important roles in many biosynthetic and biodegradative processes that span a wide range of secondary metabolite pathways and present diverse chemical transformations. In this review, we aim to provide an overview of the range of chemical transformations that P450 enzymes can catalyse within bacterial secondary metabolism, with the intention to provide an important resource to aid in understanding of the potential roles of P450 enzymes within newly identified bacterial biosynthetic pathways.
2000 年至 2018 年 细胞色素 P450（P450s）是一类含有血红素的单加氧酶超家族，在包括细菌在内的许多物种中发挥着多样化的催化作用。P450 超家族以羟化未活化的 C-H 键而闻名，但 P450 能够进行的反应多样性远远超出了这种无疑令人印象深刻的化学转化。在细菌中，P450 酶在许多生物合成和生物降解过程中发挥着重要作用，这些过程涵盖了广泛的次级代谢途径，并呈现出多样化的化学转化。在这篇综述中，我们旨在概述 P450 酶在细菌次级代谢中能够催化的一系列化学转化，旨在为理解 P450 酶在新鉴定的细菌生物合成途径中的潜在作用提供一个重要资源。
