General Surgery Unit, Department of Surgical and Oncological Science, University of Palermo, Via Liborio Giuffrè n degrees 5, Palermo, Italy.
World J Surg. 2010 Sep;34(9):2045-50. doi: 10.1007/s00268-010-0616-z.
Obesity is associated with the impairment of immunological functions. The aim of this study was to analyze some inflammatory mediators in obese subjects who underwent laparoscopic cholecystectomy.
Seventeen consecutive female patients with a BMI ranging from 35 to 45 kg/m(2) (obese) and 17 consecutive female patients with BMI ranging from 20 to 25 kg/m(2) (nonobese) were included in the study. All patients were affected by symptomatic gallbladder stone disease and underwent laparoscopic cholecystectomy. Changes in levels of leukocytes, neutrophils, IL-6, IL-10, leptin, and adiponectin were evaluated.
We observed a significant increase in leukocyte and neutrophil levels in the obese subjects compared to the nonobese subjects. The serum levels of leptin and IL-6 were higher in the postoperative period (compared to the baseline values in both groups), and always higher in the obese. Both adiponectin and IL-10 increased in the postoperative period in nonobese subjects and was always higher than in the obese.
Obese patients have a stronger acute inflammatory response than do nonobese subjects in reaction to surgical stress.
肥胖与免疫功能受损有关。本研究旨在分析腹腔镜胆囊切除术肥胖患者的一些炎症介质。
连续纳入 17 名 BMI 在 35 至 45kg/m2（肥胖）之间的女性肥胖患者和 17 名 BMI 在 20 至 25kg/m2（非肥胖）之间的女性非肥胖患者。所有患者均患有有症状的胆囊结石病并接受腹腔镜胆囊切除术。评估白细胞、中性粒细胞、IL-6、IL-10、瘦素和脂联素水平的变化。
与非肥胖组相比，肥胖组的白细胞和中性粒细胞水平明显升高。术后血清瘦素和 IL-6 水平高于两组的基线值，且在肥胖组中始终更高。非肥胖组术后脂联素和 IL-10 增加，且始终高于肥胖组。
肥胖患者对手术应激的急性炎症反应强于非肥胖患者。
