Dalzell A M, Freestone N S, Billington D, Heaf D P
Royal Liverpool Children's Hospital.
Arch Dis Child. 1990 Jun;65(6):585-8. doi: 10.1136/adc.65.6.585.
Cellobiose and mannitol were used as probe molecules to measure intestinal permeability in 36 children with cystic fibrosis, and 25 age matched controls. Orocaecal transit was also evaluated for each subject using the lactulose/hydrogen breath test. There was a fourfold increase in permeability to disaccharide (cellobiose) in patients with cystic fibrosis, but permeability to the monosaccharide (mannitol) was similar to controls. The orocaecal transit time of lactulose was prolonged in patients with cystic fibrosis, but was unrelated to the percentage excretion of cellobiose or mannitol in cystic fibrosis patients or control subjects.
以纤维二糖和甘露醇作为探针分子，对36例囊性纤维化患儿及25例年龄匹配的对照者进行肠道通透性检测。同时，采用乳果糖/氢呼气试验对每位受试者的口盲肠转运时间进行评估。囊性纤维化患者对双糖（纤维二糖）的通透性增加了四倍，但对单糖（甘露醇）的通透性与对照组相似。囊性纤维化患者的乳果糖口盲肠转运时间延长，但与囊性纤维化患者或对照者中纤维二糖或甘露醇的排泄百分比无关。
