非霍奇金恶性淋巴瘤中的染色体缺失

Chromosomal deletions in non-Hodgkin's malignant lymphomas.

作者信息

Jonveaux P, Berger R

机构信息

Unité INSERM U 301, Paris, France.

出版信息

Cancer Genet Cytogenet. 1990 Oct 15;49(2):265-9. doi: 10.1016/0165-4608(90)90151-y.

DOI:10.1016/0165-4608(90)90151-y

PMID:2208063

Abstract

The cytogenetics of 151 non-Hodgkin's malignant lymphomas (NHL) was reviewed to assess the incidence of monosomies and partial deletions. The incidence of complete or partial loss of chromosomes, possibly indicating putative tumor suppressor genes, was not significant. For chromosomes 3, 11, 13, 17, and 22, these frequencies were respectively 0%, 6.6%, 5.3%, 5.2%, and 6.6%. No specific association of deletions could be established. Three patients had a rearrangement of band 1q21 associated with deletion of chromosome 13. Finally, the most frequent chromosome segment loss in NHL involves the long arm of chromosome 6 (15.2%).

摘要

对151例非霍奇金恶性淋巴瘤（NHL）的细胞遗传学进行回顾，以评估单体性和部分缺失的发生率。染色体完全或部分缺失的发生率可能提示存在假定的肿瘤抑制基因，但并不显著。对于3号、11号、13号、17号和22号染色体，这些频率分别为0%、6.6%、5.3%、5.2%和6.6%。无法确定缺失的具体关联。3例患者存在1q21带重排并伴有13号染色体缺失。最后，NHL中最常见的染色体片段缺失涉及6号染色体长臂（15.2%）。