非霍奇金淋巴瘤中（7p13p14）的缺失

Deletion of (7p13p14) in non-Hodgkin's lymphoma.

作者信息

Jonveaux P, Le Coniat M, Derré J, Vecchione D, Berger R

机构信息

Unité INSERM U 301, Institut de Génétique Moléculaire, Paris, France.

出版信息

Cancer Genet Cytogenet. 1990 Nov 1;50(1):53-6. doi: 10.1016/0165-4608(90)90237-5.

DOI:10.1016/0165-4608(90)90237-5

PMID:2253189

Abstract

Deletion of the short arm of chromosome 7 at 7(p13p14) has been occasionally reported in non-Hodgkin's malignant lymphoma (NHL). The inclusion of this abnormality within the list of nonrandom changes awaited further data. We report three partial deletions of 7p with breakpoint at 7p13, found in various subtypes of NHL, and one deletion covering these bands (7p11 to 7p15). The association of 7p- with other chromosomal changes in the same NHL suggests that partial 7p deletion is a nonrandom secondary abnormality.

摘要

7号染色体短臂7(p13p14)缺失在非霍奇金恶性淋巴瘤（NHL）中偶尔有报道。将这种异常纳入非随机变化列表有待进一步数据支持。我们报告了3例7p部分缺失，断点位于7p13，见于NHL的不同亚型，以及1例覆盖这些条带（7p11至7p15）的缺失。同一NHL中7p-与其他染色体变化的关联提示7p部分缺失是一种非随机的继发性异常。