通过微阵列分析揭示蔓越莓来源原花青素诱导尿路致病性大肠杆菌 CFT073 进入铁限制状态。
Induction of a state of iron limitation in uropathogenic Escherichia coli CFT073 by cranberry-derived proanthocyanidins as revealed by microarray analysis.
机构信息
Dept. of Chemical Engineering, McGill University, Montreal, Quebec H3A 2B2, Canada.
出版信息
Appl Environ Microbiol. 2011 Feb;77(4):1532-5. doi: 10.1128/AEM.02201-10. Epub 2010 Dec 17.
Abstract
Transcriptional profiles of uropathogenic Escherichia coli CFT073 exposed to cranberry-derived proanthocyanidins (PACs) were determined. Our results indicate that bacteria grown on media supplemented with PACs were iron deprived. To our knowledge, this is the first time that PACs have been shown to induce a state of iron limitation in this bacterium.
摘要
检测了经蔓越莓来源原花青素（PACs）处理的尿路致病性大肠杆菌 CFT073 的转录谱。我们的结果表明，在添加 PACs 的培养基中生长的细菌缺铁。据我们所知，这是首次证明 PACs 可诱导该细菌进入缺铁状态。
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