Nat Immunol. 2011 Jan;12(1):14-6. doi: 10.1038/ni0111-14.
The molecular mechanisms that control T and T17 development and the precise role of transforming growth factor-β in this process are complex and imperfectly understood. New findings indicate that the helix-loop-helix proteins E2A and Id3 are also critically involved in some of these processes.
调控 T 和 T17 细胞发育的分子机制以及转化生长因子-β在这一过程中的精确作用非常复杂,目前人们对此了解得还不够完善。新的研究发现表明,螺旋-环-螺旋转录因子 E2A 和 Id3 也同样在其中一些过程中发挥着关键性作用。