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异氰酸酯哮喘的新方面

New aspects of isocyanate asthma.

作者信息

Baur X

机构信息

Pneumology Department, Klinikum Grosshadern, University of Munich, Federal Republic of Germany.

出版信息

Lung. 1990;168 Suppl:606-13. doi: 10.1007/BF02718184.

DOI:10.1007/BF02718184
PMID:2117170
Abstract

Air concentration of isocyanates are associated with the frequency of induced diseases. Asthma, bronchitis and rhinitis, chronic obstructive lung disease, and allergic alveolitis, respectively, were observed in exposed workers. Inhalation challenge tests with isocyanates found some 14% of symptomatic persons immunologically sensitized. At and above current threshold limit values (10 ppb) there is a risk of lung function deterioration also in asymptomatic workers.

摘要

异氰酸酯的空气浓度与职业病的发病频率相关。在接触异氰酸酯的工人中分别观察到哮喘、支气管炎和鼻炎、慢性阻塞性肺病以及过敏性肺泡炎。用异氰酸酯进行的吸入激发试验发现,约14%有症状的人出现免疫致敏。在当前阈限值(10 ppb)及以上时,无症状工人的肺功能也有恶化风险。

相似文献

1
New aspects of isocyanate asthma.异氰酸酯哮喘的新方面
Lung. 1990;168 Suppl:606-13. doi: 10.1007/BF02718184.
2
Exposure to TMXDI (meta) aliphatic isocyanate and TMI (meta) unsaturated aliphatic isocyanate. Clinical and immunological evaluation of 96 workers.接触 TMXDI(间位脂肪族异氰酸酯)和 TMI(间位不饱和脂肪族异氰酸酯)。96 名工人的临床和免疫学评估。
J Occup Med. 1993 Mar;35(3):287-90.
3
Role of inhalation challenge testing in the diagnosis of isocyanate-induced asthma.吸入激发试验在异氰酸酯诱发哮喘诊断中的作用
Chest. 1989 Feb;95(2):414-23. doi: 10.1378/chest.95.2.414.
4
Isocyanate-induced asthma: results of inhalation tests with TDI, MDI and methacholine.异氰酸酯诱发的哮喘:甲苯二异氰酸酯、二苯甲烷二异氰酸酯和乙酰甲胆碱吸入试验的结果
Int Arch Occup Environ Health. 1991;63(1):9-13. doi: 10.1007/BF00406191.
5
[Respiratory pathology of isocyanates].[异氰酸酯的呼吸病理学]
Rev Fr Mal Respir. 1983;11(5):635-44.
6
You're the flight surgeon. Isocyanates are the most common cause of occupational asthma.你是航空军医。异氰酸酯是职业性哮喘最常见的病因。
Aviat Space Environ Med. 1990 Aug;61(8):765-6.
7
[Asthma caused by isocyanate exposure].[异氰酸酯暴露引起的哮喘]
Allerg Immunol (Paris). 2002 Oct;34(8):297-301.
8
Airway isocyanate-adducts in asthma induced by exposure to hexamethylene diisocyanate.暴露于六亚甲基二异氰酸酯诱发哮喘时气道中的异氰酸酯加合物
Scand J Work Environ Health. 1997 Jun;23(3):227-31. doi: 10.5271/sjweh.203.
9
[A case of occupational asthma caused by diphenyl methane diisocyanate].[一例由二苯基甲烷二异氰酸酯引起的职业性哮喘病例]
Med Lav. 1983 Sep-Oct;74(5):391-3.
10
[On the pathogenesis of isocyanate-induced asthma].
Respiration. 1979;38(5):289-98. doi: 10.1159/000194094.

引用本文的文献

1
Occupational asthma due to isocyanates.异氰酸盐所致职业性哮喘
Lung. 1996;174(1):23-30. doi: 10.1007/BF00167948.
2
Respiratory and other hazards of isocyanates.异氰酸酯的呼吸道及其他危害。
Int Arch Occup Environ Health. 1994;66(3):141-52. doi: 10.1007/BF00380772.
3
Cellular and mediator profile in bronchoalveolar lavage of guinea pigs after toluene diisocyanate (TDI) exposure.甲苯二异氰酸酯(TDI)暴露后豚鼠支气管肺泡灌洗中的细胞和介质特征

本文引用的文献

1
Acute airway obstruction followed by hypersensitivity pneumonitis in an isocyanate (MDI) worker.一名异氰酸酯(MDI)工人出现急性气道梗阻,随后发生过敏性肺炎。
J Occup Med. 1984 Apr;26(4):285-7.
2
Detection of immunologically sensitized isocyanate workers by RAST and intracutaneous skin tests.通过放射变应原吸附试验和皮内皮肤试验检测对异氰酸酯产生免疫致敏的工人。
J Allergy Clin Immunol. 1984 May;73(5 Pt 1):610-8. doi: 10.1016/0091-6749(84)90520-7.
3
Inhibition of acetylcholinesterase by diisocyanates and its spontaneous reactivation.
Lung. 1995;173(1):57-68. doi: 10.1007/BF00167601.
4
Experimental study on respiratory sensitivity to inhaled toluene diisocyanate.吸入甲苯二异氰酸酯呼吸敏感性的实验研究
Arch Toxicol. 1993;67(6):373-8. doi: 10.1007/BF01977397.
5
Respiratory effects and skin allergy in workers exposed to tetrachloroisophthalonitrile.接触四氯间苯二甲腈的工人的呼吸道影响和皮肤过敏
Bull Environ Contam Toxicol. 1995 Aug;55(2):320-4. doi: 10.1007/BF00203028.
Int Arch Occup Environ Health. 1983;52(3):257-61. doi: 10.1007/BF00526524.
4
Immunologic cross-reactivity between different albumin-bound isocyanates.不同白蛋白结合异氰酸酯之间的免疫交叉反应性。
J Allergy Clin Immunol. 1983 Feb;71(2):197-205. doi: 10.1016/0091-6749(83)90100-8.
5
Absence of respiratory effects in subjects exposed to low concentrations of TDI and MDI.暴露于低浓度甲苯二异氰酸酯(TDI)和二苯基甲烷二异氰酸酯(MDI)的受试者未出现呼吸影响。
J Occup Med. 1982 Oct;24(10):746-50.
6
Five-year longitudinal study of workers employed in a new toluene diisocyanate manufacturing plant.对一家新建甲苯二异氰酸酯制造工厂的工人进行的为期五年的纵向研究。
Am Rev Respir Dis. 1982 Sep;126(3):420-8. doi: 10.1164/arrd.1982.126.3.420.
7
The temporal relationship between increases in airway responsiveness to histamine and late asthmatic responses induced by occupational agents.职业性因素引起的气道对组胺反应性增加与迟发性哮喘反应之间的时间关系。
J Allergy Clin Immunol. 1987 Feb;79(2):398-406. doi: 10.1016/0091-6749(87)90161-8.
8
Sensory and pulmonary irritation of methyl isocyanate in mice and pulmonary irritation and possible cyanidelike effects of methyl isocyanate in guinea pigs.异氰酸甲酯对小鼠的感觉和肺部刺激以及异氰酸甲酯对豚鼠的肺部刺激和可能的类氰化物效应。
Environ Health Perspect. 1987 Jun;72:159-67. doi: 10.1289/ehp.8772159.
9
Pulmonary and immunologic evaluation of foundry workers exposed to methylene diphenyldiisocyanate (MDI).
J Allergy Clin Immunol. 1988 Jul;82(1):55-61. doi: 10.1016/0091-6749(88)90051-6.
10
Effects of chronic exposure to diisocyanates.
Bull Eur Physiopathol Respir. 1987 Nov-Dec;23(6):561-4.