Department of Gastroenterology A, Rabta Hospital Tunis, Tunisia.
J Crohns Colitis. 2009 Jun;3(2):125-7. doi: 10.1016/j.crohns.2009.01.002. Epub 2009 Feb 4.
A part from nephrolithiasis, renal involvement is rare in the course of Crohn's disease, particularly glomerulonephritis. On the other hand, while onset of Crohn's disease is strongly influenced by environmental and genetic factors, little is known regarding influence of these factors on extra intestinal manifestations. We report a familial case of glomerulonephritis that occurred in a 38-year old woman and her mother, 59 years old with a 7-year and a 37 year history of stenosing ileocolonic disease, respectively. Both of them developed peripheral oedema with nephrotic syndrome during the course of their Crohn's disease while they had no intestinal symptoms and were not receiving any maintenance therapy. Renal function was conserved in the former while the latter developed renal failure and had already small size kidneys on abdominal sonography. Thus, renal biopsy had been performed only in the former patient and had showed membranous glomerulonephritis. Investigations showed no other underlying disease than Crohn's disease. Through this report we emphasis possible genetic influence on extra intestinal manifestations, particularly glomerulonephritis, in Crohn's disease patients.
除肾结石外，克罗恩病病程中肾脏受累很少见，特别是肾小球肾炎。另一方面，虽然克罗恩病的发病强烈受到环境和遗传因素的影响，但关于这些因素对肠道外表现的影响知之甚少。我们报告了一例家族性肾小球肾炎病例，该病例发生在一名 38 岁女性及其 59 岁母亲身上，她们分别患有狭窄性回肠结肠疾病 7 年和 37 年。在克罗恩病病程中，她们均出现外周水肿和肾病综合征，但无肠道症状且未接受任何维持治疗。前者肾功能正常，而后者则出现肾衰竭且腹部超声显示肾脏已缩小。因此，仅对前者进行了肾活检，结果显示为膜性肾小球肾炎。检查未发现除克罗恩病以外的其他潜在疾病。通过本报告，我们强调了遗传因素对克罗恩病患者肠道外表现，特别是肾小球肾炎的可能影响。
