Erasmus Medical College, Department of Clinical Microbiology and Infectious Diseases, Rotterdam, The Netherlands.
Microb Pathog. 2011 Mar-Apr;50(3-4):192-9. doi: 10.1016/j.micpath.2010.12.006. Epub 2010 Dec 21.
USA300 Staphylococcus aureus is responsible for the current outbreak of skin abscesses in the United States. Unlike other USA types, USA300 colonizes the rectum at rates higher than the nose. The reason for the difference in colonization site preference may be related to specific adherence or attachment factors contained in the genome of these strains. Additional knowledge in this field may help design novel prophylactic and therapeutic strategies to combat staphylococcal infections. Strains of USA300 MSSA and MRSA colonizing the nose and/or rectum from children with staphylococcal skin abscesses were compared by whole genome array technology to identify bacterial genetic determinants associated with site-specific colonization. Strains isolated from different colonization sites were indistinguishable by genomic content. Site-specific colonization traits were not detected in the colonizing bacteria by this array. Either host characteristics associated with staphylococcal carriage or under represented bacterial genomic constructions need to be examined to determine the etiology of this site-specific colonization.
USA300 型金黄色葡萄球菌是导致目前美国皮肤脓肿爆发的原因。与其他 USA 型不同，USA300 型在直肠中的定植率高于鼻腔。定植部位偏好差异的原因可能与这些菌株基因组中包含的特定粘附或附着因子有关。该领域的更多知识可能有助于设计新的预防和治疗策略来对抗葡萄球菌感染。通过全基因组微阵列技术比较来自患有葡萄球菌皮肤脓肿儿童的鼻腔和/或直肠定植的 USA300 MSSA 和 MRSA 菌株，以鉴定与特定部位定植相关的细菌遗传决定因素。从不同定植部位分离的菌株在基因组内容上无法区分。该阵列未在定植菌中检测到部位特异性定植特性。需要检查与葡萄球菌携带相关的宿主特征或代表性不足的细菌基因组结构，以确定这种部位特异性定植的病因。
