Riesbeck K, Forsgren A
Department of Medical Microbiology, University of Lund, Malmö General Hospital, Sweden.
Eur J Clin Microbiol Infect Dis. 1990 Jun;9(6):409-13. doi: 10.1007/BF01979471.
A study was performed to verify the effect of ciprofloxacin on the production of interleukin-2 and other cytokines in cultures of human peripheral lymphocytes. In the presence of ciprofloxacin, lymphocytes demonstrated increased synthesis of interleukin-2 (100-fold, 7-fold and 1.5-fold increase at ciprofloxacin concentrations of 80, 20 and 5 micrograms/ml respectively), as measured by radioimmunoassay. Synthesis of other cytokines from T lymphocytes, gamma-interferon, lymphotoxin and granulocyte-macrophage colony stimulating factor as well as interleukin-1 and tumour necrosis factor from monocytes was not increased, but inhibited at a ciprofloxacin concentration of 80 micrograms/ml. Thus the effect of ciprofloxacin resulting in enhanced synthesis of interleukin-2 seems to be specific.
进行了一项研究以验证环丙沙星对人外周淋巴细胞培养物中白细胞介素 -2 和其他细胞因子产生的影响。通过放射免疫测定法测量，在环丙沙星存在的情况下，淋巴细胞显示白细胞介素 -2 的合成增加（在环丙沙星浓度分别为 80、20 和 5 微克/毫升时，分别增加 100 倍、7 倍和 1.5 倍）。来自 T 淋巴细胞的其他细胞因子，γ - 干扰素、淋巴毒素和粒细胞 - 巨噬细胞集落刺激因子以及来自单核细胞的白细胞介素 -1 和肿瘤坏死因子的合成没有增加，而是在环丙沙星浓度为 80 微克/毫升时受到抑制。因此，环丙沙星导致白细胞介素 -2 合成增强的作用似乎是特异性的。
